PMID: 2113578Jun 1, 1990Paper

A proposed cause for the hepatic dysfunction associated with parenteral nutrition

Journal of Pediatric Surgery
G F WhalenJ Folkman

Abstract

Total parenteral nutrition (TPN) is associated with cholestasis and hepatic steatosis, which can be lethal in infants who cannot be fed orally. It was determined that route of administration was not the critical variable in the development of hepatic steatosis. Two groups of young rats received equivalent amounts of a standard TPN solution either orally or intravenously for an 8- to 10-day period during which they received no other nutrition. Both groups gained equivalent weight and developed marked hepatic steatosis. To test whether the solution was toxic or deficient, three groups of rats were given TPN solution orally and a fraction of their usual daily intake of rat chow. Rats receiving less than 10% of their usual chow intake developed steatosis; rats receiving more than that did not. To determine the solubility of the protective material in chow, two groups of rats were given TPN solution orally and chow that been extracted with either water or the organic solvent chloroform. Rats eating the water-extracted chow developed steatosis, rats eating chloroform-extracted chow did not. Although the protective component in chow was apparently water soluble, addition of a water soluble extract of chow to the TPN solution fed anoth...Continue Reading

References

Apr 1, 1978·Archives of Surgery·G F SheldonR Sanders
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Citations

Jul 1, 1995·Journal of Pediatric Surgery·D H TeitelbaumR E Schumacher
Jul 17, 1998·Journal of the American Dietetic Association·C J KleinC E Wiles
Jun 12, 2003·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·P VázquezA Díaz
Jun 1, 1995·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·J L Shaffer
Jul 18, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Ian P J AlwaynMark Puder
Apr 1, 1997·Scandinavian Journal of Gastroenterology·A SturmA U Dignass
Jun 1, 1995·Journal of the American College of Nutrition·E R Briones, F L Iber
Nov 3, 2010·Journal of the American Dietetic Association·Catherine J KleinLouis Scavo

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