A proposed role for diffusible signal factors in the biofilm formation and morphological transformation of Helicobacter pylori

The Turkish Journal of Gastroenterology : the Official Journal of Turkish Society of Gastroenterology
Paweł Krzyżek, Grażyna Gościniak

Abstract

Due to the increasing resistance of Helicobacter pylori to antibiotics, there is a growing need for new strategies for the effective eradication of this pathogen. The inhibition of quorum-sensing activity in most microorganisms leads to a decrease in virulence. A different reaction is observed in H. pylori, as interfering with the production of autoinducer-2 initiates biofilm formation and increases the survival of these bacteria. Therefore, it is believed that there is an alternative way to control the physiological changes of H. pylori exposed to environmental stress. In this article, we present the compounds probably involved in the modulation of H. pylori virulence. Diffusible signal factors (DSFs) are fatty acid signal molecules involved in communication between microbes. DSFs are likely to stimulate H. Pylori transition into a sedentary state that correlates with bacterial transformation into a more resistant coccoid form and initiates biofilm formation. Biofilm is a structure that plays a crucial role in protecting against adverse environmental factors (low pH, oxidative stress, action of immune system) and limiting the effective concentration of antimicrobial substances. This article has suggested and characterized the ...Continue Reading

Citations

Oct 16, 2019·Cellular and Molecular Life Sciences : CMLS·Shengbo WuJianjun Qiao
Dec 28, 2019·Helicobacter·Sara KadkhodaeiKambiz Akbari Noghabi
Oct 14, 2020·Journal of Microbiology and Biotechnology·Xing JinSeok Hoon Hong
Mar 6, 2021·BMC Microbiology·Seyedeh Zahra Bakhti, Saeid Latifi-Navid

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