A proposed staging system for rectal carcinoid tumors based on an analysis of 4701 patients

Surgery
Christine S LandryRobert C G Martin

Abstract

The lack of a clinically relevant staging system for carcinoid tumors of the rectum creates a persistent challenge for clinicians trying to provide patients with meaningful prognostic information. The purpose of this study was to identify the clinicopathologic factors that affect survival for patients diagnosed with carcinoid of the rectum, and to use this information to create a staging system. A search of 15,983 patients with carcinoid tumors from the National Cancer Institute's SEER (Surveillance Epidemiology and End Results) database identified 4701 patients with rectal carcinoid tumors from 1973 to 2004. Patients were analyzed according to various clinicopathologic factors and a tumor (T1, T2, T3), lymph node (N0, N1), and metastasis (M0, M1) staging system was created according to these parameters. The staging system was developed using log rank tests and the Cox proportional hazards model. Of the 4701 patients, 2329 females and 2372 males were identified with a median age of 56 years (14-94). Median size of primary tumor was 0.6 cm (0.1-25). Lymph node metastasis was found in 111 (4%), and distant metastatic disease was present in 97 (2.4%) patients. Rectal carcinoid was the only primary malignancy in 82% of patients; 17...Continue Reading

References

Aug 11, 1992·Diseases of the Colon and Rectum·A B JetmoreA E Timmcke
Sep 1, 1989·The Japanese Journal of Surgery·H TomodaI Hayashi
Nov 1, 1994·The Annals of Thoracic Surgery·P S PeighK S Naunheim
Feb 28, 2002·Techniques in Coloproctology·S M HeahF Seow-Choen
Feb 6, 2003·Cancer·Irvin M ModlinMark Kidd
Aug 8, 2006·Current Opinion in Gastroenterology·Andrew Y Wang, Nuzhat A Ahmad
Feb 13, 2007·Annals of Surgical Oncology·Bridget N FahyMartin R Weiser
Feb 20, 2007·World Journal of Surgical Oncology·Masashi HaraguchiTakashi Kanematsu

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Citations

Mar 19, 2014·Cirugía española·José Errasti AlustizaAngel Reina Duarte
Apr 10, 2010·World Journal of Gastroenterology : WJG·Shu-Juan NiXiang Du
May 4, 2010·Clinics in Colon and Rectal Surgery·Elizabeth A Peralta
Aug 25, 2012·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·He WangVikram Deshpande
Sep 26, 2013·AJR. American Journal of Roentgenology·Dhakshina GaneshanVikas Kundra
Apr 17, 2010·International Journal of Colorectal Disease·Sang Nam YoonJin Cheon Kim
Sep 21, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S Mocellin, D Nitti
Feb 9, 2016·Diagnostics·Emma Elizabeth IlettUlrich Knigge
Jul 29, 2010·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Andrea FrillingUrsula Plöckinger
Sep 26, 2012·Pathology International·Shunichi SasouNorihiko Kudara
Nov 22, 2012·Journal of Gastroenterology and Hepatology·Rajneesh Kumar Singh, Govindaraju Parthasarathy
Apr 12, 2016·Indian Journal of Surgical Oncology·James D Smith, Govind Nandakumar
Apr 19, 2015·World Journal of Surgical Oncology·Rockson WeiWai Lun Law
Feb 3, 2012·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Sung Ho ChunJoon-Hyuk Choi
Nov 28, 2018·Journal of Surgical Oncology·Adam C FieldsNelya Melnitchouk
Jan 18, 2018·Diseases of the Colon and Rectum·Erica S TsangHagen F Kennecke
Nov 26, 2010·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Robert C G MartinCharles R Scoggins
Dec 5, 2014·World Journal of Gastroenterology : WJG·Yihebali ChiJian-Qiang Cai
Jun 6, 2018·BMC Gastroenterology·Jihye KimJoo Sung Kim
Sep 4, 2020·World Journal of Gastrointestinal Oncology·Yong-Jun YuShi-Wu Zhang
Nov 20, 2012·Oncology Letters·Daisuke YamagishiNaohiro Tomita
Jul 22, 2019·Best Practice & Research. Clinical Endocrinology & Metabolism·Louis de MestierPhilippe Ruszniewski
Aug 3, 2021·Journal of the National Comprehensive Cancer Network : JNCCN·Manisha H ShahCindy Hochstetler

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