A prospective analysis of circulating saturated and monounsaturated fatty acids and risk of non-Hodgkin lymphoma

International Journal of Cancer. Journal International Du Cancer
Yu-Han ChiuBrenda M Birmann

Abstract

Circulating saturated (SFA) and monounsaturated fatty acids (MUFA), which are predominantly derived from endogenous metabolism, may influence non-Hodgkin lymphoma (NHL) risk by modulating inflammation or lymphocyte membrane stability. However, few biomarker studies have evaluated NHL risk associated with these fats. We conducted a prospective study of 583 incident NHL cases and 583 individually matched controls with archived pre-diagnosis red blood cell (RBC) specimens in the Nurses' Health Study (NHS) and Health Professionals Follow-Up Study (HPFS). RBC membrane fatty acid levels were measured using gas chromatography. Using multivariable logistic regression, we estimated odds ratios (OR) and 95% confidence intervals (CI) for risk of NHL and major NHL subtypes including T cell NHL (T-NHL), B cell NHL (B-NHL) and three individual B-NHLs: chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma. RBC SFA and MUFA levels were not associated with NHL risk overall. However, RBC very long chain SFA levels (VLCSFA; 20:0, 22:0, 23:0) were inversely associated with B-NHLs other than CLL/SLL; ORs (95% CIs) per standard deviation (SD) increase in level were 0.81 (0.70...Continue Reading

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Citations

Dec 28, 2018·International Journal of Cancer. Journal International Du Cancer·Marta SolansDelphine Casabonne
Jan 11, 2020·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Xinping LiYuanyuan Li
Oct 7, 2020·The American Journal of Clinical Nutrition·Andres V Ardisson KoratBrenda M Birmann
Aug 7, 2021·Nutrition and Cancer·Silvia GiannattasioLaura Di Renzo

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