A prospective analysis of micronutrient status in quiescent inflammatory bowel disease.

Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition
Morag Jane MacMasterDaniel R Gaya

Abstract

ESPEN guidelines advocate patients with inflammatory bowel disease (IBD) have their micronutrient levels checked regularly. This study described the micronutrient status of patients with quiescent IBD and explores whether biochemical micronutrient deficiencies related to time to subsequent disease relapse. Sixteen micronutrients were measured prospectively in blood of patients with IBD in clinical remission [Harvey Bradshaw Index (HBI) ≤4 in Crohn's disease (CD) and a partial Mayo score <2 in ulcerative colitis (UC)]. Patients were followed prospectively using the electronic patient records. The ability of micronutrient status to predict time to relapse was tested with survival analysis and Cox regression. Ninety-three patients were enrolled; Fifty (54%) were also in biochemical remission defined as a normal faecal calprotectin (<250 μg/g), C-reactive protein (<10 mg/L) and serum albumin (>35 g/L). Deficiencies in vitamin D were identified in 27 (29%), zinc in 15 (16%), vitamin B6 in 13 (14%), vitamin C in 12 (13%) and vitamin B12 in 10 (11%). Fewer participants had low serum folate 7 (8%), ferritin 8 (9%), copper 4 (4%), magnesium 4 (4%) and plasma selenium 3 (3%). Zinc deficiency was predictive of a shorter time to subsequent...Continue Reading

Citations

Sep 20, 2020·Journal of Crohn's & Colitis·Jean-Pierre HugotUlrich Meinzer
Jan 6, 2021·International Journal of Molecular Sciences·Carolina BattistiniJun Sun
May 1, 2021·Nutrients·Lorenzo BertaniFrancesco Costa
May 3, 2021·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Lorcan McGroganKonstantinos Gerasimidis
Aug 28, 2021·Nutrients·Georgiana-Emmanuela Gîlcă-BlanariuGabriela Ștefănescu

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