A prospective analysis of microsatellite instability as a molecular marker in colorectal cancer

American Journal of Surgery
Eugene Y ChangJoseph Frankhouse

Abstract

Microsatellite instability (MSI) may be a molecular marker of colorectal tumor biology. We sought to evaluate the incidence and significance of MSI in an unselected colorectal cancer population. Colorectal cancer cases from a community health system were prospectively evaluated for MSI and patient outcomes monitored. Of 240 eligible, 140 underwent testing; 43 (31%) had high-frequency MSI (MSI-H). Those with MSI-H tumors presented with earlier disease stage (P = .014) and lymphocytic infiltration (P < .001). Stage III MSI-H patients trended toward improved disease-free survival (P = .065). MSI-H patients were more likely to have other primary malignancies. Prevalence of MSI-H in the general colorectal cancer population is higher than previously reported. MSI testing of colorectal cancers is useful as part of a molecular profile to stratify patients for prognosis, treatment, and further study. Patients with MSI-H tumors are more likely to have other primary malignancies, suggesting a role for heightened screening.

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Citations

May 24, 2013·Molecular Genetics and Genomics : MGG·Xiaoyan DuZhenwen Chen
Apr 25, 2014·Gastroenterology Report·Marlies S ReimersCornelis J H van de Velde
Jun 30, 2010·The Oncologist·Vanessa DeschoolmeesterJan B Vermorken
Oct 10, 2014·Journal of Surgical Oncology·Daniel O Herzig, Vassiliki L Tsikitis
Feb 16, 2013·Arquivos Brasileiros De Cirurgia Digestiva : ABCD = Brazilian Archives of Digestive Surgery·Graziele Moraes LossoIara Taborda Messias-Reason
Oct 27, 2007·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Kjetil Søreide
Jan 12, 2021·Familial Cancer·George Kunnackal JohnFrancis M Giardiello

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