A Prospective Birth Cohort Study on Early Childhood Lead Levels and Attention Deficit Hyperactivity Disorder: New Insight on Sex Differences

The Journal of Pediatrics
Yuelong JiXiaobin Wang

Abstract

To investigate the prospective associations between early childhood lead exposure and subsequent risk of attention deficit hyperactivity disorder (ADHD) in childhood and its potential effect modifiers. We analyzed data from 1479 mother-infant pairs (299 ADHD, 1180 neurotypical) in the Boston Birth Cohort. The child's first blood lead measurement and physician-diagnosed ADHD was obtained from electronic medical records. Graphic plots and multiple logistic regression were used to examine dose-response associations between lead exposure and ADHD and potential effect modifiers, adjusting for pertinent covariables. We found that 8.9% of the children in the Boston Birth Cohort had elevated lead levels (5-10 µg/dL) in early childhood, which was associated with a 66% increased risk of ADHD (OR, 1.66; 95% CI, 1.08-2.56). Among boys, the association was significantly stronger (OR, 2.49; 95% CI, 1.46-4.26); in girls, the association was largely attenuated (P value for sex-lead interaction = .017). The OR of ADHD associated with elevated lead levels among boys was reduced by one-half if mothers had adequate high-density lipoprotein levels compared with low high-density lipoprotein, or if mothers had low stress compared with high stress dur...Continue Reading

References

May 1, 1980·Archives of Toxicology·A A Wibowo, R L Zielhuis
Oct 1, 1996·Environmental Health Perspectives·R A Goyer
Jun 12, 1998·Brain Research. Brain Research Reviews·Y FinkelsteinJ F Rosen
Mar 4, 2000·Environmental Health Perspectives·A O Onalaja, L Claudio
Jun 10, 2000·Journal of the American Academy of Child and Adolescent Psychiatry·T G O'Connor, M Rutter
May 17, 2001·Public Health Reports·P J Landrigan
Jan 12, 2002·JAMA : the Journal of the American Medical Association·Xiaobin WangXiping Xu
Dec 13, 2002·Brain : a Journal of Neurology·Theodore I Lidsky, Jay S Schneider
Jan 28, 2004·Annual Review of Pharmacology and Toxicology·Lucio G CostaOffie Porat Soldin
Mar 12, 2004·Journal of the International Neuropsychological Society : JINS·M Douglas RisRobert L Bornschein
Jan 15, 2005·Journal of Abnormal Child Psychology·Gerald R PattersonMarion S Forgatch
Mar 10, 2005·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Alina Rodriguez, Gunilla Bohlin
Apr 7, 2005·Environmental Health Perspectives·Marija PopovicWendy E Kaye
Jun 6, 2006·Environmental Geochemistry and Health·Moussa M DiawaraJames Carsella
Aug 8, 2006·Neurotoxicology·Steven G Gilbert, Bernard Weiss
Sep 26, 2006·Environmental Research·Marie VahterMarika Berglund
Dec 23, 2006·Environmental Health Perspectives·Joe M BraunBruce P Lanphear
Sep 14, 2007·Journal of Abnormal Child Psychology·Kate J LiffordAnita Thapar
Jun 20, 2008·Environmental Geochemistry and Health·Richard Campanella, Howard W Mielke
Oct 23, 2008·Environmental Health Perspectives·Hui-Li WangDi-Yun Ruan
Sep 11, 2010·Environmental Health Perspectives·Paul A EubigSusan L Schantz
Sep 28, 2010·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Stephen ScottMoira Doolan
Feb 20, 2013·Clinical Psychology Review·James K GoodladJessica J Fulton
Jul 16, 2013·American Journal of Obstetrics and Gynecology·Yunxian YuXiaobin Wang
Nov 22, 2013·The Annals of Pharmacotherapy·Alok Sharma, Justin Couture
Feb 13, 2014·JAMA : the Journal of the American Medical Association·Guoying WangXiaobin Wang
Apr 24, 2014·Journal of Exposure Science & Environmental Epidemiology·Zhu ChenXiaobin Wang
Dec 1, 2005·Psychological Science in the Public Interest : a Journal of the American Psychological Society·Laura Hubbs-TaitDavid C Bellinger
Sep 16, 2016·American Journal of Public Health·Katherine A AhrensYutaka Aoki
May 16, 2017·JAMA Pediatrics·David C BellingerBruce P Lanphear

❮ Previous
Next ❯

Citations

Jan 15, 2019·Psychological Medicine·Nicholas H NguyenStephen J Glatt
May 29, 2019·Current Opinion in Neurology·Tamara MayNicole J Rinehart
Sep 23, 2020·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Neha S AnandXiaobin Wang
Feb 1, 2019·International Journal of Environmental Research and Public Health·Gabriele DonzelliMaría Morales-Suárez-Varela
Aug 28, 2020·The American Journal of Clinical Nutrition·Ramkripa RaghavanXiaobin Wang
Mar 27, 2021·Environmental Health and Preventive Medicine·Isabella KarakisLena Novack
Mar 28, 2021·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Malavika LPraveen Sharma
Mar 30, 2021·Current Epidemiology Reports·Julia A BauerBirgit Claus Henn
Jul 3, 2021·International Journal of Environmental Research and Public Health·Dylan B Jackson, Alexander Testa
Sep 25, 2021·Autism Research : Official Journal of the International Society for Autism Research·Ashley Sang Eun LeeXiaobin Wang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.