PMID: 1201630Jul 1, 1975Paper

A prospective clinical trial of post-operative radiotherapy delivered in three fractions per week versus two fractions per week in breast carcinoma

Clinical Radiology
T D Bates

Abstract

The results are presented of a five-year prospective trial of 411 patients with breast carcinoma treated by mastectomy and post-operative radiotherapy. Twice or thrice weekly dose-fractionation techniques were used, i.e. 12 fractions in 28 days and six fractions in 18 days. The results show that, in terms of survival and control of local disease, the two techniques are very similar. The early and late radiation effects on the normal tissues up to five years are similar and acceptable. Dose levels thought to be biologically equivalent on the basis of experience at St Thomas's Hosiptal were selected. It is stressed that there is a narrower margin of normal tissue tolerance when six fractions over 18 days are used, that it is essential to treat all fields on each treatment occasion and that the total maximum tissue dose of 3600 R is not exceeded. Attention is drawn to the fact that the dose for six fractions, derived from the NSD formula which would be predicted to be equivalent to the 12-fraction dose is, in fact, over 10% higher than the dose used here and likely to produce unacceptable late radiation changes.

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Citations

Jan 1, 1977·International Journal of Radiation Oncology, Biology, Physics·H R WithersJ B Smathers
Aug 1, 1989·International Journal of Radiation Oncology, Biology, Physics·T Bates
Jul 13, 2000·International Journal of Radiation Oncology, Biology, Physics·B JonesS J Khaksar
Oct 1, 1987·The British Journal of Radiology·O C Scott
Nov 1, 1981·International Journal of Radiation Oncology, Biology, Physics·W T SauseD D Levitt
Feb 1, 1979·The British Journal of Radiology·H F Moustafa, J W Hopewell
May 1, 1991·Clinical Oncology : a Journal of the Royal College of Radiologists·M N GazeH W Rooke
Nov 1, 1995·Cancer·A Recht, M J Houlihan
Jan 25, 2005·Breast Cancer Research and Treatment·Max ManoPeter Canney
Jul 19, 2016·The Cochrane Database of Systematic Reviews·Brigid E HickeyAdrienne M See
Mar 7, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A RechtUNKNOWN American Society of Clinical Oncology
Mar 1, 1986·Acta Radiologica. Oncology·E K YeohM F Spittle

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