A prospective comparative study of interaction between lithium and modified electroconvulsive therapy

The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry
Jagadisha ThirthalliBangalore N Gangadhar

Abstract

To compare patients on lithium and those not on lithium with regard to adverse effects while receiving ECT. Inpatients with schizophrenia, non-organic psychosis, mania and depression, who were prescribed ECTs either on (n=27) or not (n=28) on lithium were studied. Clinicians blind to lithium-status recorded seizure parameters, interaction with succinyl choline, cardiovascular response, recovery from ECT and immediate post-ECT complications. The lithium group showed no significant difference in terms of seizure variables, apnea time, and recovery from anaesthesia when compared to the non-lithium group. Average maximum heart rate, average maximum systolic blood pressure and average maximum rate pressure product were significantly lower in patients who had combined lithium and ECT. In lithium patients the average time to post-ECT recovery was directly correlated with serum lithium level. Though concurrent lithium is by and large safe during ECT, it benefits to maintain serum lithium level at lower end of therapeutic range. However, the findings can be applied to relatively young patients with no risk factors for ECT-complications.

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Citations

Dec 17, 2010·Expert Review of Neurotherapeutics·Hazem Shoirah, Hesham M Hamoda
Mar 23, 2013·General Hospital Psychiatry·Suneetha Karkada SadanandaSuresh Bada Math
Dec 28, 2011·International Review of Psychiatry·Paul E CroarkinJon Lee
Dec 3, 2014·Asian Journal of Psychiatry·Preeti JacobJohn Vijay Sagar
Aug 16, 2016·The Psychiatric Clinics of North America·Chittaranjan AndradeJagadisha Thirthalli
Jun 25, 2015·Australasian Psychiatry : Bulletin of Royal Australian and New Zealand College of Psychiatrists·Jacqueline P Huber, David Burke
May 17, 2019·The Journal of ECT·Takashi TsujiiHiroyuki Uchida
Nov 26, 2019·The Journal of ECT·Takashi TsujiiHiroyuki Uchida
May 10, 2020·Indian Journal of Psychiatry·Sandeep GroverAjit Avasthi
Oct 4, 2019·Indian Journal of Psychiatry·Sucharita MandalSuchandra K Hari Hara
Nov 11, 2020·The American Journal of Psychiatry·Alby EliasHarold A Sackeim
Oct 26, 2021·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Ricardo Martins-AscencaoNuno Trovão

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