A Prospective Comparison of the Effects of Interfractional Variations on Proton Therapy and Intensity Modulated Radiation Therapy for Prostate Cancer

International Journal of Radiation Oncology, Biology, Physics
M MoteabbedHsiao-Ming Lu

Abstract

To quantify and compare the impact of interfractional setup and anatomic variations on proton therapy (PT) and intensity modulated radiation therapy (IMRT) for prostate cancer. Twenty patients with low-risk or intermediate-risk prostate cancer randomized to receive passive-scattering PT (n=10) and IMRT (n=10) were selected. For both modalities, clinical treatment plans included 50.4 Gy(RBE) to prostate and proximal seminal vesicles, and prostate-only boost to 79.2 Gy(RBE) in 1.8 Gy(RBE) per fraction. Implanted fiducials were used for prostate localization and endorectal balloons were used for immobilization. Patients in PT and IMRT arms received weekly computed tomography (CT) and cone beam CT (CBCT) scans, respectively. The planned dose was recalculated on each weekly image, scaled, and mapped onto the planning CT using deformable registration. The resulting accumulated dose distribution over the entire treatment course was compared with the planned dose using dose-volume histogram (DVH) and γ analysis. The target conformity index remained acceptable after accumulation. The largest decrease in the average prostate D98 was 2.2 and 0.7 Gy for PT and IMRT, respectively. On average, the mean dose to bladder increased by 3.26 ± 7.5...Continue Reading

References

Jul 15, 1995·International Journal of Radiation Oncology, Biology, Physics·P OkunieffH D Suit
Jan 1, 1993·International Journal of Radiation Oncology, Biology, Physics·A Niemierko, M Goitein
Jan 18, 2006·International Journal of Radiation Oncology, Biology, Physics·Loïc FeuvretPierre Bey
Jan 24, 2007·International Journal of Radiation Oncology, Biology, Physics·Xiaodong ZhangRadhe Mohan
May 22, 2007·International Journal of Radiation Oncology, Biology, Physics·Alexei TrofimovWilliam U Shipley
Oct 2, 2007·International Journal of Radiation Oncology, Biology, Physics·Carlos VargasSameer Keole
Feb 1, 2008·International Journal of Radiation Oncology, Biology, Physics·Myonggeun YoonKwan Ho Cho
Oct 23, 2008·Journal of the American College of Cardiology·Anthony N DeMaria
Nov 19, 2008·International Journal of Radiation Oncology, Biology, Physics·Kevin C BylundJohn M Buatti
Oct 6, 2009·International Journal of Radiation Oncology, Biology, Physics·Martin SoukupMarkus Alber
May 11, 2010·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Robert Jan SmeenkJohannes H A M Kaanders
Nov 3, 2010·International Journal of Radiation Oncology, Biology, Physics·Stefan BothNeha Vapiwala
Nov 26, 2010·International Journal of Radiation Oncology, Biology, Physics·Nancy P MendenhallRandal Henderson
Dec 3, 2011·International Journal of Radiation Oncology, Biology, Physics·Shikui TangHsiao-Ming Lu
Aug 7, 2012·Physics in Medicine and Biology·Ning WenIndrin J Chetty
Oct 10, 2012·Physics in Medicine and Biology·Benjamin M ClasieHanne M Kooy
Dec 18, 2012·Journal of the National Cancer Institute·James B YuCary P Gross

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Citations

Jun 20, 2017·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Yoshitomo AbeKeiichi Jingu
Jun 6, 2019·Journal of Applied Clinical Medical Physics·France CarrierJay Burmeister
Jan 20, 2022·Journal of Applied Clinical Medical Physics·Hiroshi TamuraHiroki Shirato

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