PMID: 3766208Jan 1, 1986Paper

A prospective critical evaluation of in vitro thyroid function tests

Acta Medica Scandinavica
U B Ericsson, J I Thorell

Abstract

A number of 2 325 serum samples from a population of in- and outpatients were collected during a six-month period in order to evaluate the usefulness of various thyroid function tests in the clinical laboratory routine. The samples were analysed with the following thyroid function tests: total triiodothyronine (T3) (TT3), total thyroxine (T4) (TT4), free T3 index (FT3I), free T4 index (FT4I) and thyrotropin (TSH). One to two years after the primary evaluation, a follow-up was performed and the final diagnoses were checked in the patients' records. The values of these parameters in the diagnosis of hyperthyroidism were: FT3I greater than FT4I greater than TT3 greater than TT4. The corresponding results in the diagnosis of hypothyroidism were: TSH greater than FT4I greater than FT3I = TT3. No single test could detect both hyper- and hypothyroidism effectively. The only one-step strategy for thyroid evaluation in patients without apparent clinical signs of hyper- or hypothyroidism would therefore be the combined determination of T3 and TSH. The study also showed distinct differences between the reference values of the healthy population and patients without thyroid disorders.

References

Sep 1, 1978·Scandinavian Journal of Clinical and Laboratory Investigation·K Rootwelt, H E Solberg
Jul 1, 1975·The Journal of Clinical Endocrinology and Metabolism·F BermudezJ H Oppenheimer
Aug 12, 1976·European Journal of Nuclear Medicine·A V StepanasM N Maisey
Aug 9, 1975·British Medical Journal·K E BrittonR P Ekins
Sep 11, 1975·The Journal of Clinical Investigation·S NomuraT Shimizu
Apr 21, 1973·British Medical Journal·D B BarnettR N Smith
Jun 1, 1969·Acta Endocrinologica·K Liewendahl, B A Lamberg
Aug 1, 1973·The Journal of Clinical Endocrinology and Metabolism·H A RubensteinS C Werner
Oct 1, 1973·Clinical Endocrinology·Y C Patel, H G Burger
Apr 1, 1971·Annals of Internal Medicine·J M Hershman, J A Pittman
Jun 1, 1981·The Journal of Clinical Endocrinology and Metabolism·E M KapteinJ T Nicoloff
Feb 1, 1982·The Journal of Clinical Endocrinology and Metabolism·S MelmedJ M Hershman
Sep 1, 1984·Scandinavian Journal of Clinical and Laboratory Investigation·G LindstedP A Lundberg
Sep 1, 1981·Clinical Endocrinology·J R StockigtD M Hurley

❮ Previous
Next ❯

Citations

Jan 1, 1990·Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum·N R KeidingC E Mabeck

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.