A prospective evaluation of antral follicle function in women with 46,XX spontaneous primary ovarian insufficiency.

Fertility and Sterility
Ziad R HubayterLawrence M Nelson

Abstract

To assess ovarian follicle function in women with 46,XX spontaneous primary ovarian insufficiency. Case-control with nested prospective cohort. Clinical Research Center, National Institutes of Health. Women with primary ovarian insufficiency without estrogen replacement for 2 weeks (N = 97) and regularly menstruating control women (N = 42). Single injection of 300 IU hrFSH. Change in serum estradiol at 24 hours. Antral follicles ≥3 mm were detected in 73% (69/95) of patients; both serum estradiol and progesterone levels correlated significantly with maximum follicle diameter in these women. Patients with a maximum follicle diameter ≥8 mm had significantly higher serum estradiol and progesterone levels and significantly lower FSH and LH levels compared with patients without such follicles. In controls estradiol levels increased significantly after FSH administration, but in patients this was not the case despite the presence of an antral follicle ≥8 mm. Most women with 46,XX spontaneous primary ovarian insufficiency have antral follicles detectable by ultrasound, suggesting that down-regulation of FSH receptors is not the predominant mechanism of follicle dysfunction. Evidence of progesterone secretion by antral follicles ≥8 mm ...Continue Reading

References

Apr 1, 1975·The Journal of Clinical Investigation·B M Sherman, S G Korenman
Apr 11, 1992·The Journal of Clinical Endocrinology and Metabolism·E L YongS G Hillier
Dec 28, 1972·The New England Journal of Medicine·D RabinW Polishuk
Jan 1, 1966·The Journal of Clinical Endocrinology and Metabolism·K J Ryan, Z Petro
Dec 1, 1982·Fertility and Sterility·C B Coulam
Jun 1, 1993·Current Opinion in Obstetrics & Gynecology·R S Morris, M V Sauer
Aug 1, 1993·Biology of Reproduction·M DuncanK Chada
Feb 1, 1996·Fertility and Sterility·G S ConwayH S Jacobs
Aug 28, 1997·The New England Journal of Medicine·L C LaymanJ L Jameson
Oct 22, 1963·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·T G BAKER
Feb 7, 2009·The New England Journal of Medicine·Lawrence M Nelson

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Citations

Dec 23, 2011·International Journal of Endocrinology·Pantelis TsimarisDeligeoroglou Efthymios
Feb 14, 2016·Climacteric : the Journal of the International Menopause Society·R J BaberUNKNOWN IMS Writing Group
Feb 6, 2013·The Journal of Obstetrics and Gynaecology Research·Isao TsujiNahoko Fujinami
Jan 9, 2014·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Hiroyuki HonnmaToshiaki Endo
Jun 27, 2015·Disease Markers·Farzaneh AlipourMasoumeh Hosseinpoor
Sep 2, 2016·Reproduction : the Official Journal of the Society for the Study of Fertility·P GrasaS A Williams
Nov 4, 2016·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Mahiru KawanoHirohisa Kurachi
Jun 21, 2011·Menopause : the Journal of the North American Menopause Society·Lawrence M Nelson
Jun 19, 2015·Current Opinion in Pediatrics·Catherine M GordonLawrence M Nelson
Jan 11, 2012·Nature Reviews. Endocrinology·Jenny A VisserAxel P N Themmen
Jul 13, 2021·Frontiers in Genetics·Kensuly C PiedadeLawrence M Nelson

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