A prospective evaluation of the effects of salpingectomy on endometrial lymphocyte clusters in patients with hydrosalpinges

Fertility and Sterility
Chikako ItoShigehiko Mizutani

Abstract

To investigate the effect of hydrosalpinges on embryo implantation. Prospective study. Private fertility and university hospitals. Eighteen patients with unilateral or bilateral hydrosalpinges who underwent salpingectomy. Pre- and posttreatment endometrial biopsies for immunohistochemical evaluation. Pre- and posttreatment lymphocyte populations in endometrial samples, evaluated by immunohistochemical identification. Endometrial samples from pretreatment exhibited small lymphocytic clusters of CD3+, CD8+, CD4+, granzyme B positive, and CD56+. After salpingectomy, the numbers of cluster lesions were significantly decreased. Because a characteristic distribution of lymphocytes in endometrium with hydrosalpinges was found, activation of T/NK (natural killer) lymphocytes in endometrium might be involved in the impairment of embryo implantation in cases of hydrosalpinges.

References

Nov 1, 1996·Human Reproduction Update·J Paavonen, M Lehtinen
Jul 1, 1997·Human Reproduction·W R MeyerB A Lessey
Jan 10, 2002·Fertility and Sterility·Anne KinnunenHeljä Marja Surcel

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Citations

Apr 26, 2017·American Journal of Reproductive Immunology : AJRI·Louise KofodThomas Vauvert F Hviid

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