A prospective fMRI-based technique for localising the epileptogenic zone in presurgical evaluation of epilepsy

NeuroImage
Borbala HunyadiWim Van Paesschen

Abstract

There is growing evidence for the benefits of simultaneous EEG-fMRI as a non-invasive localising tool in the presurgical evaluation of epilepsy. However, many EEG-fMRI studies fail due to the absence of interictal epileptic discharges (IEDs) on EEG. Here we present an algorithm which makes use of fMRI as sole modality to localise the epileptogenic zone (EZ). Recent studies using various model-based or data-driven fMRI analysis techniques showed that it is feasible to find activation maps which are helpful in the detection of the EZ. However, there is lack of evidence that these techniques can be used prospectively, due to (a) their low specificity, (b) selecting multiple activation maps, or (c) a widespread epileptic network indicated by the selected maps. In the current study we present a method based on independent component analysis and a cascade of classifiers that exclusively detects a single map related to interictal epileptic brain activity. In order to establish the sensitivity and specificity of the proposed method, it was evaluated on a group of 18 EEG-negative patients with a single well-defined EZ and 13 healthy controls. The results show that our method provides maps which correctly indicate the EZ in several (N=4)...Continue Reading

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Citations

Aug 4, 2015·Frontiers in Human Neuroscience·Jian QinHui Shen
Oct 15, 2019·Frontiers in Neurology·Elhum A ShamshiriSerge Vulliemoz
Dec 24, 2019·Cerebral Cortex·Francisco GilAntonio Donaire
Aug 21, 2019·Frontiers in Neurology·Simon Van EyndhovenSabine Van Huffel
Nov 26, 2020·Epilepsia·Sara LarivièreBoris C Bernhardt

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