A Prospective Hospital Study to Evaluate the Diagnostic Accuracy of Rapid Diagnostic Tests for the Early Detection of Leptospirosis in Laos

The American Journal of Tropical Medicine and Hygiene
S DittrichK Woods

Abstract

Leptospirosis is a globally important cause of acute febrile illness, and a common cause of non-malarial fever in Asia, Africa, and Latin America. Simple rapid diagnostic tests (RDTs) are needed to enable health-care workers, particularly in low resource settings, to diagnose leptospirosis early and give timely targeted treatment. This study compared four commercially available RDTs to detect human IgM against Leptospira spp. in a head-to-head prospective evaluation in Mahosot Hospital, Lao PDR. Patients with an acute febrile illness consistent with leptospirosis (N = 695) were included in the study during the 2014 rainy season. Samples were tested with four RDTs: ("Test-it" [Life Assay, Cape Town, South Africa; N = 418]; "Leptorapide" [Linnodee, Ballyclare, Northern Ireland; N = 492]; "Dual Path Platform" [DPP] [Chembio, Medford, NY; N = 530]; and "SD-IgM" [Standard Diagnostics, Yongin, South Korea; N = 481]). Diagnostic performance characteristics were calculated and compared with a composite reference standard combining polymerase chain reaction (PCR) (rrs), microscopic agglutination tests (MATs), and culture. Of all patients investigated, 39/695 (5.6%) were positive by culture, PCR, or MAT. The sensitivity and specificity o...Continue Reading

References

Apr 9, 2001·Clinical Microbiology Reviews·P N Levett
Jan 5, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Cathy A PettiMerle A Sande
Oct 10, 2006·Clinical and Vaccine Immunology : CVI·Stuart D BlacksellPaul N Newton
Jan 6, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Stuart D BlacksellNicholas P J Day
Apr 24, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Direk LimmathurotsakulSharon J Peacock
Jul 31, 2012·QJM : Monthly Journal of the Association of Physicians·A E ForbesV Sivaprakasam
Nov 8, 2012·PLoS Neglected Tropical Diseases·Scott A NabityAlbert I Ko
Feb 19, 2013·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·F ChappuisC P Yansouni
Jul 23, 2013·PLoS Neglected Tropical Diseases·Marga G A GorisKimberly R Boer
Sep 21, 2013·Epidemiology and Infection·T BrownlowW A Ellis
Oct 29, 2013·BMJ : British Medical Journal·Christiana A NaaktgeborenJohannes B Reitsma
Nov 12, 2013·Diagnostic Microbiology and Infectious Disease·Mathieu PicardeauRudy A Hartskeerl
Feb 28, 2014·The New England Journal of Medicine·Valérie D'AcremontBlaise Genton
Apr 22, 2014·The Lancet Global Health·Mayfong MayxayPaul N Newton
Feb 13, 2015·World Journal of Virology·Rushna FirdausProvash Chandra Sadhukhan
Sep 18, 2015·PLoS Neglected Tropical Diseases·Federico CostaAlbert I Ko

❮ Previous
Next ❯

Citations

Apr 22, 2020·Disaster Medicine and Public Health Preparedness·Ian MarrNicholas Coatsworth
Jul 18, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sunil PokharelSabine Dittrich
Feb 26, 2020·Scientific Reports·Soon-Hian TehCheng-Yoong Pang

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR

Software Mentioned

STATA
MedCalc

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antibodies: Agglutination

Antibody-mediated agglutination is the clumping of cells in the presence of antibody, which binds multiple cells together. This enhances the clearance of pathogens. Find the latest research on antibody-mediated agglutination here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Related Papers

Transactions of the Royal Society of Tropical Medicine and Hygiene
Ampai TanganuchitcharnchaiStuart D Blacksell
Journal of Clinical and Diagnostic Research : JCDR
Summaiya Mullan, Tanvi Harivadanbhai Panwala
Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
F ChappuisC P Yansouni
© 2022 Meta ULC. All rights reserved