A prospective investigation of predictive parameters for post-surgical recurrences in sinonasal polyposis

European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
Giuseppe BresciaAlessandro Martini

Abstract

Even after appropriate surgical therapy, a significant number of patients with chronic rhinosinusitis with nasal polyps (CRSwNP) experience recurrences. The end-point of this prospective study was to apply univariate and multivariate statistical models to identify clinical, pathological, and laboratory variables that could predict CRSwNP recurrence after endoscopic sinus surgery. The study enrolled 143 patients between 2010 and 2013, who were all treated by the same surgeon for CRSwNP. Twenty-one patients developed recurrent polyposis. The recurrence rate was significantly higher for the eosinophilic than for the non-eosinophilic type (p = 0.020). Among the patients who developed a recurrence, the disease-free interval was significantly shorter for those with eosinophilic-type polyposis (p = 0.003). Univariate statistical analysis disclosed significant associations between CRSwNP recurrence and age (p = 0.035), allergy (p = 0.014), and eosinophilic granulomatosis with polyangiitis (p = 0.01). The multivariate model showed that only histological evidence of the eosinophilic type of CRSwNP retained an independent prognostic significance in relation to recurrent polyposis (p = 0.033). Judging from our results, it is reasonable to ...Continue Reading

References

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Citations

Oct 26, 2018·American Journal of Rhinology & Allergy·Nuray Bayar MulukGuy Scadding
Jan 6, 2021·Immunity, Inflammation and Disease·Annina LylySanna Toppila-Salmi
Feb 24, 2021·American Journal of Otolaryngology·Giuseppe BresciaGino Marioni
May 18, 2021·Allergy & Rhinology·Markus Jukka LiljaSanna Katriina Toppila-Salmi
Nov 8, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Yanran HuangClaus Bachert

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