A prospective non-interventional study for evaluation of quality of life in patients with Alzheimer's disease treated with rivastigmine transdermal patch

SAGE Open Medicine
Vassileios VagenasMichail Vikelis

Abstract

The primary objective of this multicentre, prospective, observational study was to assess whether there is improvement in the patients' quality of life under treatment with rivastigmine transdermal patch, as it is evaluated both by patients and their caregivers. Compliance to treatment and safety were secondary endpoints. In total, 1509 patients with mild to moderate Alzheimer's disease, already treated with rivastigmine transdermal patch 4.6 or 9.5 mg/24 h, were enrolled within a 2.4-month period and prospectively followed up for 2 months on an outpatient basis. The 'Quality of Life in Alzheimer's disease (QOL-AD): Patient and Caregiver Report' questionnaire was used to evaluate quality of life as an effectiveness measure. A significant improvement in quality of life, as indicated by a change of 2.7 and 2.5 points in the mean patients' and caregiver's QOL-AD: Patient and Caregiver Report score respectively (both p < 0.001) from baseline to end of study was recorded. No serious adverse events were reported. Compliance was high, with 100% compliance reported for almost 9 out of 10 patients at study end.

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Citations

Mar 29, 2016·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Mary-Carmel KearneyRyan F Donnelly
May 29, 2012·Revista española de geriatría y gerontología·Daniel RodríguezUNKNOWN Grupo de Trabajo de Demencias de la Sociedad Catalana de Geriatría y Gerontología

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Software Mentioned

AD
OPTIMA
QOL
SPSS

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