A prospective observational study of the effect of penicillin skin testing on antibiotic use in the intensive care unit

Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America
Mercedes E ArroligaA C Arroliga

Abstract

Patients with penicillin allergy admitted to the intensive care unit (ICU) frequently receive non-beta-lactam antimicrobials for the treatment of infection. The use of these antimicrobials, more commonly vancomycin and fluoroquinolones, is associated with the emergence of multidrug-resistant infections. The penicillin skin test (PST) can help detect patients at risk of developing an immediate allergic reaction to penicillin and those patients with a negative PST may be able to use a penicillin antibiotic safely. We determined the incidence of true penicillin allergy, the percentage of patients changed to a beta-lactam antimicrobial when the test was negative, the safety of the test, and the safety of administration of beta-lactam antimicrobials in patients with a negative test. Skin testing was performed using standard methodology. One hundred patients admitted to 4 ICUs were prospectively studied; 58 of them were male. The mean age was 63 years. Ninety-six patients had the PST: one was positive (1.04%), 10 (10.4%) were nondiagnostic, and 85 (88.5%) were negative. Of the 38 patients who received antimicrobials for therapeutic reasons, 31(81.5%) had the antibiotic changed to a beta-lactam antimicrobial after a negative reading v...Continue Reading

References

May 1, 1992·Archives of Internal Medicine·R Y Lin
Feb 1, 1990·Postgraduate Medicine·J E Erffmeyer, M S Blaiss
Aug 8, 1998·Annals of Internal Medicine·D VillersH Richet
Aug 25, 1999·The American Journal of Medicine·A D HarrisM H Samore
Feb 7, 2001·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·R SolenskyR S Gruchalla
Oct 13, 2000·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·R SolenskyR S Gruchalla
Dec 2, 2000·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·M A Valyasevi, R G Van Dellen
Apr 9, 2001·Critical Care Medicine·M S Niederman
May 22, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D M ForrestP M Dodek
Aug 7, 2001·Annals of Internal Medicine·S K FridkinUNKNOWN Intensive Care Antimicrobial Resistance Epidemiology (ICARE) Project and the National Nosocomial Infections Surveillance (NN

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Citations

Aug 30, 2006·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Eric Macy
Aug 30, 2006·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Benjamin B L WongSusan Waserman
Apr 27, 2007·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Gonzalo Alvarez del RealMercedes E Arroliga
Jan 13, 2006·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Kamalini NadarajahMary Naglak
Oct 16, 2013·Current Opinion in Infectious Diseases·Jason Trubiano, Elizabeth Phillips
Jan 21, 2014·Intensive Care Medicine·Ramzy H Rimawi, Mark A Mazer
May 27, 2014·Infectious Disease Clinics of North America·Keith W Hamilton, Neil O Fishman
Feb 26, 2014·The Journal of Allergy and Clinical Immunology. in Practice·Matthieu PicardLouis Paradis
Dec 1, 2012·The Journal of Allergy and Clinical Immunology·Roland Solensky
Oct 12, 2010·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·UNKNOWN Joint Task Force on Practice ParametersUNKNOWN Joint Council of Allergy, Asthma and Immunology
Nov 26, 2015·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Mercedes E ArroligaAlejandro C Arroliga
Nov 29, 2005·The Medical Clinics of North America·Roland Solensky
Nov 7, 2006·Immunology and Allergy Clinics of North America·Paul A Greenberger
May 29, 2013·Pharmacotherapy·Nathan R UngerLinda W Cheung
Sep 27, 2006·The American Journal of Medicine·Justin L RanesAlejandro C Arroliga
May 12, 2015·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Bob GengMarc A Riedl
Apr 9, 2015·Family Practice·Odette A E SaldenBerna D L Broekhuizen
Nov 6, 2013·The Journal of Allergy and Clinical Immunology·Eric Macy, Richard Contreras
Mar 4, 2017·The Journal of Allergy and Clinical Immunology·Kimberly G BlumenthalRochelle P Walensky
Jun 3, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jerome A LeisElizabeth Weber
Jan 24, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kimberly G BlumenthalErica S Shenoy
Dec 7, 2018·British Journal of Clinical Pharmacology·Rebekah MoranJason A Trubiano
Jun 9, 2010·The Korean Journal of Internal Medicine·So Hee LeeYou Young Kim
Jun 4, 2010·Critical Care Medicine·Salmaan Kanji, Clarence Chant
Jan 22, 2020·Critical Care Nurse·Homood A Alharbi
May 26, 2017·Current Allergy and Asthma Reports·Justin R Chen, David A Khan
Jul 7, 2018·Open Forum Infectious Diseases·Justin R ChenDavid A Khan
Feb 6, 2017·The Annals of Pharmacotherapy·Prasanna P Narayanan, Meghan N Jeffres
Mar 30, 2018·Open Forum Infectious Diseases·Nicholas A TurnerDeverick J Anderson
May 10, 2017·The Journal of Allergy and Clinical Immunology. in Practice·Kimberly G BlumenthalPaige G Wickner
Jun 10, 2021·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Jessica L SeidelmanSarah S Lewis

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