Abstract
Acute radiation-induced esophagitis (ARIE) is one of main toxicities complicated by thoracic radiotherapy, influencing patients' quality of life and radiotherapy proceeding seriously. It is difficult to be cured rapidly so far. Our phase I trial preliminarily showed that EGCG may be a promising strategy in the treatment of ARIE. We prospectively enrolled patients with stage III lung cancer from the Shandong Tumor Hospital & Institute in China from January 2013 to September 2014. All patients received concurrent or sequential chemo-radiotherapy, or radiotherapy only. EGCG was administrated once ARIE appeared. EGCG was given with the concentration of 440μmol/L during radiotherapy and additionally two weeks after radiotherapy. RTOG score, dysphagia and pain related to esophagitis were recorded every week. Thirty-seven patients with stage IIIA and IIIB lung cancer were enrolled in this trial. In comparison to the original, the RTOG score in the 1st, 2nd, 3rd, 4th, 5th week after EGCG prescription and the 1st, 2nd week after radiotherapy decreased significantly (P=0.002, 0.000, 0.000, 0.001, 0.102, 0.000, 0.000, respectively). The pain score of each week was significantly lower than the baseline (P=0.000, 0.000, 0.000, 0.000, 0.006,...Continue Reading
References
Jul 24, 1998·Mutation Research·H FujikiK Nakachi
Aug 22, 2002·Redox Report : Communications in Free Radical Research·Guangjun NieBaolu Zhao
Apr 27, 2004·Cancer·Stephen T SonisUNKNOWN International Society for Oral Oncology
Apr 1, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Benjamin MovsasRoger Byhardt
May 14, 2005·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Jose BelderbosJoos Lebesque
Jun 7, 2005·International Journal of Radiation Oncology, Biology, Physics·Ken TakedaShogo Yamada
Sep 6, 2007·Blood·Werner Hunstein
May 31, 2008·Nature Structural & Molecular Biology·Dagmar E EhrnhoeferErich E Wanker
Oct 28, 2008·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Jim RoseDavid D'Souza
May 20, 2009·Proceedings of the National Academy of Sciences of the United States of America·Ilona HauberJoachim Hauber
Mar 31, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anne AupérinJean-Pierre Pignon
Apr 28, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Felix Y FengAvraham Eisbruch
Jun 8, 2010·The New England Journal of Medicine·F Stephen HodiWalter J Urba
Jun 10, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Yoshihiko SegawaMitsune Tanimoto
Jun 11, 2010·The Journal of Nutrition·Munkyong PaeDayong Wu
Aug 11, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Joshua D BrodyRonald Levy
Jul 6, 2011·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Richard Peter HillSalomeh Jelveh
Jul 12, 2011·FEBS Letters·Nelson FerreiraMaria Rosário Almeida
Oct 25, 2011·Molecular Aspects of Medicine·Dayong WuSimin Nikbin Meydani
Nov 15, 2011·Toxicology and Applied Pharmacology·Fen WuMax Costa
Mar 24, 2012·International Journal of Radiation Oncology, Biology, Physics·Mary FengTheodore S Lawrence
Dec 12, 2012·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Jasper NijkampJan-Jakob Sonke
Jan 8, 2013·Journal of the National Cancer Institute·Silvia C Formenti, Sandra Demaria
Apr 25, 2013·Journal of the American Chemical Society·Fernando L PalhanoJeffery W Kelly
Aug 13, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Blaz GroseljAnne E Kiltie
Jan 8, 2014·Toxicology Mechanisms and Methods·Zhen AnYingmei Zhang
Jan 9, 2014·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Jan 22, 2014·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Hanxi ZhaoLigang Xing
Feb 25, 2014·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Chad TangDaniel R Gomez
Jul 30, 2014·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Abraham J WuAndrew Jackson
Dec 4, 2014·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Ting XuDaniel R Gomez
Citations
Mar 13, 2016·The American Journal of Pathology·Beng San YeohMatam Vijay-Kumar
Oct 27, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Sumit KumarRamovatar Meena
Jul 12, 2016·Seminars in Cancer Biology·Suleman S HussainRita Ghosh
Jun 25, 2016·Current Medical Research and Opinion·Bingyan GongYue Zhao
Dec 13, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chung S Yang, Hong Wang
Mar 24, 2018·Nutrition and Cancer·Sunil Kumar DhatwaliaDevinder K Dhawan
Mar 15, 2019·Critical Reviews in Food Science and Nutrition·Xiao-Yu XuHua-Bin Li
Nov 9, 2019·Investigational New Drugs·Wanqi ZhuJinming Yu
Nov 21, 2019·Journal of Medicinal Food·Xiaoling LiJinming Yu
May 26, 2016·Oncotarget·Wanqi ZhuMeizhu Zheng
Apr 2, 2019·Molecular and Clinical Oncology·Alexandr ShumskyFedor Petrovskiy
Dec 3, 2016·Molecular Medicine Reports·Kamran HaratiMustafa Becerikli
Jun 2, 2017·International Journal of Cancer. Journal International Du Cancer·Jianmin HuYa Cao
Jun 7, 2018·Frontiers in Pharmacology·Chuan-Hao JiangWen-Qun Li
Dec 31, 2016·Chinese Journal of Integrative Medicine·Li-Juan WangBao-Lin Qu
Mar 13, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Liu-Xiang WangXin-Qiang Zheng
Sep 26, 2017·Oncology Letters·Liang LiuGuangda Wang
Nov 14, 2019·Chinese Medicine·Hua LuoYitao Wang
Oct 24, 2019·Oncology Letters·Dilyara Radikovna KaidarovaFedor Igorevich Petrovskiy
Apr 16, 2020·Cancers·Ammad Ahmad FarooqiAamir Ahmad
Nov 15, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Asad UllahMariusz Jaremko
Nov 19, 2020·Anais Da Academia Brasileira De Ciências·Shady M MostafaAbdelgawad A Fahmi
Aug 21, 2020·Archives of Biochemistry and Biophysics·Ran WeiGerardo G Mackenzie
May 1, 2021·Cells·Madhu Kollareddy, Luis A Martinez
Jun 29, 2021·Frontiers in Oncology·Wanqi ZhuJinming Yu
Oct 19, 2020·Free Radical Biology & Medicine·Li-Wei XieYe Tian
Jul 24, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Jyoti SinghAbha Meena
Aug 28, 2021·Nutrients·Giuseppina AugimeriDaniela Bonofiglio