A prospective population-based management program including primary surgery and postoperative risk assessment by means of DNA ploidy and histopathology. Adjuvant radiotherapy is not necessary for the majority of patients with FIGO stage I-II endometrial cancer

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
T HogbergSouthern Swedish Gynecologic Oncology Group

Abstract

A management program for FIGO stage I-II nonserous, nonclear-cell adenocarcinomas was evaluated. Histopathology and DNA ploidy were used to estimate postoperatively the risk of progression or death of disease and to tailor treatment. The patient material was a population-based consecutive cohort of all women with endometrial cancer in the Southern Swedish Health Care Region diagnosed between June 1993 and June 1996 (n = 553). Of these, 335 were eligible for the management program. Patients estimated to be at low risk were treated by surgery only, while high-risk patients also received vaginal brachytherapy. A large low-risk group consisting of 84% (n = 283) of the patients with an estimated disease-specific 5-year survival of 96% (95% CI = 93-98%) was identified. The high-risk group (n = 52, 16%) showed a worse outcome with an 80% 5-year disease-specific survival (95% CI = 65-89%). The difference in survival between the groups was highly significant (P < 0.0001). Half of the progressions were distant in the high-risk group. Although there is a clear indication for adjuvant therapy for this group, locoregional radiotherapy could be expected to fail in cases with distant progression. Thus, effective systemic treatments need to be...Continue Reading

References

May 1, 1976·Journal of the National Cancer Institute·N B Atkin
Sep 1, 1991·International Journal of Radiation Oncology, Biology, Physics·K M GrevenP E Hogan
Jan 1, 1990·Critical Reviews in Oncology/hematology·B Lindahl
Oct 1, 1986·American Journal of Obstetrics and Gynecology·O E Iversen
Jan 1, 1985·Computer Programs in Biomedicine·T Hakulinen, K H Abeywickrama
Nov 1, 1983·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·D W HedleyE A Musgrove
May 1, 1995·Gynecologic Oncology·R M Lanciano, K M Greven
Nov 1, 1995·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·T MagginoA Gadducci
Nov 15, 1995·Cancer·D E Henson, L A Ries
Feb 1, 1996·Gynecologic Oncology·H G Ball
Jan 1, 1996·Acta Oncologica·N Einhorn
Jul 27, 1999·Gynecologic Oncology·H AshihA Berchuck
Mar 1, 1995·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·P. AlmT. Högberg
Dec 1, 2001·International Journal of Radiation Oncology, Biology, Physics·C L CreutzbergUNKNOWN PORTEC Study Group. The Postoperative Radiation Therapy in Endometrial Carcinoma

❮ Previous
Next ❯

Citations

May 17, 2005·Gynecologic Oncology·Andrea MarianiKarl C Podratz
Mar 22, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G MangiliG Taccagni
Oct 4, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M PradhanB Å Risberg
Oct 7, 2011·ISRN Obstetrics and Gynecology·Sheng-Mou Hsiao, Lin-Hung Wei
Nov 26, 2015·Nature Reviews. Clinical Oncology·Håvard E DanielsenMarco Novelli
Apr 16, 2011·Gynecologic Oncology·Taejong SongByoung-Gie Kim
May 3, 2012·Acta Obstetricia Et Gynecologica Scandinavica·Henrik LajerOle Mogensen
Aug 16, 2005·International Journal of Radiation Oncology, Biology, Physics·Tamim M NiaziGerald Stanimir
Oct 6, 2009·American Journal of Obstetrics and Gynecology·Elisabeth WikHelga B Salvesen
Nov 14, 1998·Journal of Molecular Biology·N YeT R O'Connor
Oct 23, 2010·Molecular Cell·Alberto Ciccia, Stephen J Elledge
Sep 13, 2005·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Carla MerisioMauro Melpignano
Nov 9, 2005·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·P UharcekJ Ravinger
May 27, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Manohar PradhanBjörn Ake Risberg
Dec 7, 2007·Obstetrics and Gynecology·Janice S KwonHelen C Ettler
Oct 1, 2010·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Manohar PradhanHåvard Emil Danielsen
Jul 4, 2009·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Bengt SorbeB Frankendal
Sep 24, 2005·The Oncologist·David T Shaeffer, Marcus E Randall
Jun 3, 2017·Journal of Dental Education·Douglas A YoungPeter Rechmann
Feb 1, 2013·Community Dentistry and Oral Epidemiology·Douglas A Young, John D B Featherstone
May 16, 2017·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Teresia SvanvikJanusz Marcickiewicz
May 1, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M PradhanB Å Risberg

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.