A Prospective, Population-based Study to Determine the Incidence and Bacteriology of Bacterial Conjunctivitis in Children <2 Years of Age Following 7-Valent and 13-Valent Pneumococcal Conjugate Vaccine Sequential Implementation.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Ron DaganNoga Givon-Lavi

Abstract

Bacterial conjunctivitis is most commonly caused by nontypeable Haemophilus influenzae (NTHi), followed by Streptococcus pneumoniae. No population-based data on the impact of pneumococcal conjugate vaccines (PCVs) on the incidence of bacterial conjunctivitis have been published. We assessed rate dynamics of overall, pneumococcal, and NTHi conjunctivitis in children aged 2-23 months in southern Israel before and after PCV implementation. This is a 12-year prospective, population-based surveillance, from July 2004 through June 2017. Our medical center serves a captive population of approximately 30 000 children < 2 years of age, and its clinical microbiology laboratory processes > 80% of all community-derived cultures, enabling incidence calculation. The 7-valent and 13-valent PCVs (PCV7 and PCV13, respectively) were implemented in the national immunization program in July 2009 and November 2010, respectively. Pneumococci, NTHi, Moraxella catarrhalis, and Streptococcus pyogenes were considered pathogens. Continuous annual incidences and incidence rate ratios comparing the PCV13 period (2015-2017) to the pre-PCV period (2004-2008) were calculated. Disease caused by PCV13 serotypes declined by 93%, without significant replacement w...Continue Reading

References

Apr 1, 1981·The Journal of Pediatrics·F GigliottiJ Wood
Jun 1, 1995·Pediatrics in Review·F Gigliotti
May 19, 2000·Antimicrobial Agents and Chemotherapy·S L BlockD W Stroman
Sep 9, 2005·The Pediatric Infectious Disease Journal·Nava BuznachDavid Greenberg
Jun 9, 2009·The Pediatric Infectious Disease Journal·Galia BarkaiRon Dagan
Nov 27, 2009·BMC Ophthalmology·Andrew F Smith, Curtis Waycaster
Sep 4, 2012·Vaccine·S Ben-ShimolUNKNOWN Israeli Bacteremia and Meningitis Active Surveillance Group
Aug 28, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Shalom Ben-ShimolRon Dagan
May 27, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Shalom Ben-ShimolRon Dagan
May 12, 2018·The Pediatric Infectious Disease Journal·Daniel GlikmanUNKNOWN Israel Bacteremia and Meningitis Active Surveillance Group
Oct 4, 2018·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Kosuke NagaiYutaka Terao

❮ Previous
Next ❯

Citations

May 21, 2021·Emerging Infectious Diseases·Matt WassermanStephen Pelton
Aug 24, 2021·Expert Review of Vaccines·Emily K HornRaymond A Farkouh

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Pneumonia (ASM)

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Bacterial Pneumonia

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.