A prospective randomised controlled trial of operative versus non-operative management of fractures of the humeral diaphysis: the HUmeral Shaft Fracture FIXation (HU-FIX) Study protocol

Trials
William M OliverSamuel G Molyneux

Abstract

Humeral shaft fractures constitute around 1% of adult fractures in the UK, with an annual incidence of approximately 13 per 100,000 population. Historically, these injuries have been primarily managed non-operatively, with operative fixation reserved for specific indications. Although some recent retrospective studies have suggested there are potential benefits of operative fixation over humeral bracing, there is a deficiency in level 1 evidence to support operative management as the primary treatment for humeral shaft fractures. This single-centre prospective randomised controlled trial aims to recruit 70 adult patients with an isolated closed fracture of the humeral diaphysis into one of two treatment arms: operative (n = 35) or non-operative (n = 35). The operative arm will undergo open reduction and internal fixation (ORIF) of the fracture using a standard fixation technique (plate and screws). The non-operative arm will be fitted with a prefabricated humeral brace until fracture union. All patients will be followed up for 1 year post-intervention. The primary outcome measure will be the Disabilities of the Arm, Shoulder and Hand (DASH) score at 3 months post-intervention. Secondary outcome measures will include pain, treat...Continue Reading

Associated Clinical Trials

Sep 28, 2018·William Oliver

References

Jan 1, 1992·Injury·P Camden, S Nade
Jan 1, 1986·Archives of Orthopaedic and Trauma Surgery·L Naver, J R Aalberg
Mar 1, 1985·The Journal of Bone and Joint Surgery. British Volume·M J BellR Y McMurtry
Apr 13, 2000·The Journal of Bone and Joint Surgery. American Volume·A SarmientoC A Capps
Jul 1, 1997·The Journal of the American Academy of Orthopaedic Surgeons·P R Gregory, R W Sanders
May 17, 2000·The Journal of Bone and Joint Surgery. British Volume·R G McCormackE H Schemitsch
Jun 15, 2000·Archives of Orthopaedic and Trauma Surgery·T FjalestadB Rostad
May 4, 2002·Journal of Shoulder and Elbow Surgery·Peter P KochChristian Gerber
Dec 22, 2004·International Orthopaedics·J A K ToivanenM J Järvinen
Sep 1, 2005·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Kenneth RockwoodArnold Mitnitski
Jun 6, 2006·Acta Orthopaedica·Mohit BhandariEmil H Schemitsch
Jul 4, 2006·Injury·Charles M Court-Brown, Ben Caesar
Nov 1, 2006·The Journal of Bone and Joint Surgery. British Volume·R EkholmS Ponzer
Nov 3, 2006·The Journal of Bone and Joint Surgery. American Volume·Andrew JawaDavid Ring
Nov 8, 2006·Journal of Orthopaedic Trauma·Marijn Rutgers, David Ring
Jul 25, 2007·The British Journal of Radiology·C J Martin
Apr 8, 2009·Journal of Clinical Epidemiology·Daniel Schwartz, Joseph Lellouch
Jan 11, 2013·BMJ : British Medical Journal·An-Wen ChanDavid Moher
Nov 2, 2013·The Journal of Orthopaedic and Sports Physical Therapy·Franco FranchignoniGiorgio Ferriero
Apr 14, 2016·BMC Musculoskeletal Disorders·Carl BergdahlMichael Möller
Apr 5, 2017·The Journal of Bone and Joint Surgery. American Volume·Fabio Teruo MatsunagaJoao Carlos Belloti
May 10, 2017·Journal of Orthopaedics and Traumatology : Official Journal of the Italian Society of Orthopaedics and Traumatology·Bradley S SchochSurena Namdari
Oct 22, 2017·Journal of Shoulder and Elbow Surgery·Frances E Harkin, Richard J Large
Sep 21, 2018·Trauma Surgery & Acute Care Open·Graeme M RosenbergThomas G Weiser

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Citations

May 13, 2020·JAMA : the Journal of the American Medical Association·Lasse RämöUNKNOWN FISH Investigators
Mar 9, 2021·Geriatric Orthopaedic Surgery & Rehabilitation·Sanjit R KondaKenneth A Egol
Mar 25, 2021·The Journal of Hand Surgery, European Volume·Peter CayDavid Ricketts
Apr 8, 2021·Operative Orthopädie und Traumatologie·Martin H Hessmann, Thomas Mittlmeier

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