A prospective, randomized, blinded, placebo-controlled pilot study on the effect of Enterococcus faecium on clinical activity and intestinal gene expression in canine food-responsive chronic enteropathy

Journal of Veterinary Internal Medicine
Silke SchmitzK Allenspach

Abstract

Canine chronic enteropathies (CE) are believed to be caused by an aberrant immune response towards the intestinal microbiome. Administration of probiotics can alleviate colitis in people. In vitro effects of the probiotic Enterococcus faecium NCIMB 10415 E1707 (EF) previously have been evaluated using canine cells (e.g., whole blood, intestinal biopsies), but data on in vivo efficacy are lacking. Administration of EF to dogs with food-responsive CE will improve clinical outcome and decrease the intestinal inflammatory profile. Dogs diagnosed with CE were prospectively recruited to receive a hydrolyzed elimination diet plus either a synbiotic product containing EF or placebo for 6 weeks. Both veterinary staff and owners were blinded to the treatment. Clinical severity index (CCECAI), clinicopathological data and gene expression using intestinal biopsies (TLR2/4/5/9, IL-17A, IL-22, IL-23p19, RORC, IL-2, IL-12p35, TNFα, IL-4, IFNy, IL-10, TGFβ, IL-1β, IL-18, NLRP3, casp-1, TFF1, TFF3 and PPARy) before and after 6 weeks of treatment were analyzed using linear mixed modeling. Of the 45 cases recruited, 12 finished the clinical trial. Seven received the synbiotic and 5 the placebo product. There was no difference between groups or tr...Continue Reading

References

Feb 3, 1998·Cellular and Molecular Life Sciences : CMLS·L Thim
Jan 5, 2002·Scandinavian Journal of Gastroenterology. Supplement·R K LinskensS G Meuwissen
Mar 4, 2003·Nature Immunology·Jason D FontenotAlexander Y Rudensky
Apr 22, 2005·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·S Di CaroA Gasbarrini
Dec 22, 2005·Infection and Immunity·Peter TyrerJennelle M Kyd
Jul 27, 2006·Journal of Animal Physiology and Animal Nutrition·S N SauterJ W Blum
Sep 29, 2006·Folia Microbiologica·M MarcinákováA Lauková
Mar 22, 2007·PloS One·Benoit FoligneCorinne Grangette
Aug 22, 2007·Journal of Veterinary Internal Medicine·K AllenspachF Gaschen
Feb 1, 2008·Proceedings of the National Academy of Sciences of the United States of America·Alexandra AreVelmurugesan Arulampalam
Feb 7, 2008·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Lorrie GaschenAndrea Gröne
May 10, 2008·Journal of Veterinary Internal Medicine·I A BurgenerT W Jungi
Aug 5, 2008·Journal of Veterinary Internal Medicine·N M S SchreinerK Allenspach
Oct 22, 2008·Proceedings of the National Academy of Sciences of the United States of America·Harry SokolPhilippe Langella
Feb 5, 2009·Proceedings of the National Academy of Sciences of the United States of America·Peter van BaarlenMichiel Kleerebezem
Jan 29, 2010·Seminars in Immunopathology·Keiji HirotaMarc Veldhoen
Apr 15, 2010·Journal of Veterinary Internal Medicine·R J WashabauUNKNOWN WSAVA International Gastrointestinal Standardization Group
Jul 31, 2010·Gut Microbes·Carissa M Thomas, James Versalovic
Jun 14, 2012·PLoS Pathogens·Seong Gyu JeonKiyoshi Takeda
Jun 19, 2012·Trends in Endocrinology and Metabolism : TEM·Walter Wahli, Liliane Michalik
Nov 28, 2012·Veterinary Immunology and Immunopathology·Silke SchmitzKarin Allenspach
May 15, 2013·Journal of Veterinary Internal Medicine·D WalkerO A Garden

❮ Previous
Next ❯

Citations

May 31, 2017·Journal of Veterinary Internal Medicine·M A OyamaP A Shaw
Jul 18, 2019·Journal of Veterinary Internal Medicine·Anders P Jensen, Charlotte R Bjørnvad
Aug 31, 2020·Microbial Biotechnology·Giulia AlessandriMarco Ventura
Dec 14, 2018·Journal of Veterinary Internal Medicine·Kelly MakielskiAlbert E Jergens
Jul 17, 2020·Frontiers in Microbiology·Susan M WernimontJan S Suchodolski
Aug 29, 2020·Journal of Veterinary Internal Medicine·Rachel PillaJan S Suchodolski
Feb 12, 2017·The Journal of Small Animal Practice·T Krentz, S Allen
Aug 14, 2019·International Journal of Molecular Sciences·Ghalia KhoderSherif M Karam
Feb 6, 2019·TheScientificWorldJournal·Matteo CerquetellaSilvia Vincenzetti
Nov 15, 2020·The Veterinary Clinics of North America. Small Animal Practice·Silke Salavati Schmitz
Nov 3, 2020·The Veterinary Clinics of North America. Small Animal Practice·Aarti Kathrani

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsies
biopsy
PCR
sedation

Software Mentioned

Primer3

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.