A prospective randomized clinical trial comparing D2 dissection in laparoscopic and open gastrectomy for gastric cancer

Medical Oncology
Ming CuiXiangqian Su

Abstract

Laparoscopic surgery is an acceptable alternative to open surgery in colorectal cancer treatment. However, in gastric cancer, there is not much scientific evidence. Here, we proposed a prospective randomized clinical trial to evaluate the radicalness and safety of laparoscopic D2 dissection for gastric cancer. From October 2010 to September 2012, 300 patients with gastric cancer were randomized to undergo either laparoscopy-assisted gastrectomy (LAG) or conventional open gastrectomy (OG) with D2 dissection. Clinicopathological parameters, recovery and complications were compared between these two groups. Thirty cases were excluded because of refusing to be involved in the trial, having peritoneal seeding metastasis or LAG conversed to OG, and finally 270 cases were analyzed (128 in LAG and 142 in OG). No significant differences were observed in gender, age, body mass index, stages and types of radical resection [radical proximal gastrectomy (PG + D2), radical distal gastrectomy (DG + D2) and radical total gastrectomy (TG + D2)] (P > 0.05). The number of harvested lymph nodes (HLNs) was similar (29.3 ± 11.8 in LAG vs. 30.1 ± 11.4 in OG, P = 0.574). And in the same type of radical resection, no significant difference was found in...Continue Reading

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Citations

Jun 22, 2018·Updates in Surgery·Wietse J EshuisSuzanne S Gisbertz
Sep 7, 2018·Expert Review of Anticancer Therapy·Lei Huang, Tuan-Jie Li
Feb 13, 2020·Surgical Laparoscopy, Endoscopy & Percutaneous Techniques·Ken HagiwaraYoritaka Matsuno
Apr 5, 2019·Journal of Gastric Cancer·UNKNOWN Guideline Committee of the Korean Gastric Cancer Association (KGCA), Development Working Group & Review Panel
Jul 6, 2019·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Gijsbert I van BoxelRichard van Hillegersberg
Jun 15, 2020·World Journal of Surgical Oncology·Zhipeng ZhuZhengjie Huang
Jan 29, 2020·World Journal of Surgical Oncology·Furong ZengGuangtong Deng
May 18, 2016·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Daniela TreitlKfir Ben-David
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Nov 28, 2020·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·Kaja LudwigUwe Scharlau

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