A prospective randomized clinical trial of perioperative treatment with octreotide in pancreas transplantation

American Journal of Surgery
E BenedettiR Pollak

Abstract

Technical failures continue to plague clinical pancreas transplantation. The somastatin analogue octreotide has been shown able to decrease morbidity after pancreatic resection. We studied the effect of perioperative treatment with octreotide on technical complications after pancreas transplant. Seventeen recipients of bladder-drained transplant were randomized to receive either octreotide, 100 microg TID SQ for 5 days after transplant (n = 10) or no additional treatment (n = 7). We compared the two groups in terms of patient and graft survival and incidence of graft pancreatitis, intra-abdominal infections, and anastomotic leaks. In the untreated group, 1 patient developed a bladder leak and 2 had intra-abdominal infections, while no complications occurred in the octreotide-treated patients (P = 0.05). Six-month patient and pancreas survival was 100% and 90%, respectively, in octreotide-treated patients versus 86% and 86% in the control group (P = NS). Perioperative treatment with octreotide seems able to reduce the incidence of technical complications after pancreas transplantation.

Citations

Nov 13, 2003·Transplantation Proceedings·N S HakimV Papalois
Apr 25, 2000·American Journal of Surgery·R J KnightT M Fishbein
Aug 19, 2009·Topics in Magnetic Resonance Imaging : TMRI·Rana FattahiFrank R Burton
Jul 18, 2002·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·M FalconiP Pederzoli
Nov 16, 2004·Anesthesiology Clinics of North America·William T Merritt
Oct 4, 2006·Current Opinion in Anaesthesiology·D E KoehntopK G Belani
Jan 14, 2021·World Journal of Transplantation·Joana Ferrer-Fàbrega, Laureano Fernández-Cruz

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