A prospective randomized comparison between long and discontinuous-long protocols of gonadotropin-releasing hormone agonist for in vitro fertilization

Fertility and Sterility
S FujiiY Saito

Abstract

To investigate the efficacy of a discontinuous-long protocol in an IVF program. Prospective randomized study. University hospital. One hundred thirty-seven IVF cycles of 92 patients in an outpatient IVF program from April 1995 to December 1995. In the discontinuous-long protocol group (n = 68), GnRH agonist (GnRH-a) was administered from the luteal phase until cycle day 7, when pure FSH administration was begun. In the long protocol group (n = 69), GnRH-a was administered until the day before hCG administration. Serum LH and ovarian steroid hormone levels, and IVF outcome. The period and the total dosage of hMG were increased in the discontinuous-long protocol group. Although the fertilization rate was similar under both protocols, the number of embryos transferred was smaller and the cancellation rate was higher in the discontinuous-long protocol group because of the greater failure of oocyte retrieval and fertilization. Serum E2 levels in the late follicular phase were lower in the discontinuous-long protocol group. Early discontinuation of GnRH-a is not beneficial because of its adverse effects on follicular development.

Citations

Jul 14, 2001·European Journal of Obstetrics, Gynecology, and Reproductive Biology·N NikolettosK Diedrich
Sep 21, 2000·European Journal of Obstetrics, Gynecology, and Reproductive Biology·N NikolettosK Diedrich
Sep 16, 2000·Molecular and Cellular Endocrinology·P N BarriA Veiga
Sep 20, 2005·Reproductive Biomedicine Online·Roberto MarciMassimo Moscarini
Jul 7, 1999·American Journal of Reproductive Immunology : AJRI·A FukuiY Saito
Jun 15, 2013·Reproductive Biomedicine Online·Li-Jun DingHai-Xiang Sun
Jun 3, 2006·Reproductive Biomedicine Online·Juan Balasch, Francisco Fábregues
Apr 12, 2005·Fertility and Sterility·Arnold H M SimonsSimon A Schoonderwoerd
Dec 3, 2014·Reproductive Biomedicine Online·Mohamed A AboulgharRagaa T Mansour
Sep 5, 2012·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·R MarciM Moscarini
Nov 13, 2015·The Cochrane Database of Systematic Reviews·Charalampos S SiristatidisSiladitya Bhattacharya

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