A prospective, randomized, controlled trial comparing three different gonadotropin regimens in oocyte donors: ovarian response, in vitro fertilization outcome, and analysis of cost minimization

Fertility and Sterility
Marco Antonio Barreto MeloJosé Remohí

Abstract

To compare the efficacy of three different gonadotropin regimens in an oocyte donation program. The analysis of cost minimization also was evaluated. Prospective, randomized, controlled study. Instituto Universitario-IVI, Valencia, Spain. One thousand twenty-eight donors undergoing a GnRH agonist protocol were assigned randomly to one of three groups: group 1 (n=346), only recombinant FSH (rFSH); group 2 (n=333), only highly purified menotropin (HP-hMG); and group 3 (n=349), rFSH plus HP-hMG. One thousand seventy-nine oocyte recipients. Controlled ovarian stimulation. Controlled ovarian stimulation parameters, IVF outcome, and cost analysis. No differences were found among the groups with respect to days of stimulation, gonadotropin dose, final E2 and P levels, number of oocytes retrieved, and cancellation rate. Similarly, there were no differences among the groups in terms of embryo development parameters. Moreover, implantation, pregnancy, and miscarriage rates with the three regimens were similar. However, the cost of rFSH was greater than that of the other protocols. This study suggests that in the GnRH agonist protocol the three different gonadotropin regimens evaluated herein are equally effective. Protocols using HP-hMG ...Continue Reading

References

Jun 1, 1995·Human Reproduction·J RemohíA Pellicer
Apr 4, 1998·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·R AgrawalH S Jacobs
Sep 7, 2002·Fertility and Sterility·UNKNOWN European and Israeli Study Group on Highly Purified Menotropin versus Recombinant Follicle-Stimulating Hormone
Dec 25, 2002·Human Reproduction Update·Marco FilicoriDomenico DeAloysio
Feb 7, 2003·Human Reproduction·Hesham Al-InanyGamal Serour
May 2, 2006·Human Reproduction·M A B MeloJ Remohí
Jul 21, 2007·Human Reproduction·Søren ZiebeUNKNOWN MERIT (Menotrophin vs Recombinant FSH in vitro Fertilisation Trial) Group
Nov 22, 2007·Reproductive Biomedicine Online·Jaroslaw WechowskiRichard Kennedy
Feb 7, 2008·Reproductive Biomedicine Online·Hesham G Al-InanyGamal I Serour
Aug 7, 2008·Reproductive Biomedicine Online·Peter PlatteauPaul Devroey

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Citations

Aug 27, 2013·Clinical Drug Investigation·Maria-Reyes LorenteFernando Antoñanzas
Aug 11, 2011·Human Reproduction·Marcos MeseguerJose Remohí
Mar 4, 2014·Reproductive Biomedicine Online·Jesús AguilarMarcos Meseguer
Oct 10, 2015·Archives of Gynecology and Obstetrics·R GomezC Skala
Oct 3, 2013·Fertility and Sterility·Javier HerreroMarcos Meseguer
Apr 7, 2012·Fertility and Sterility·Marcos MeseguerSteen Laursen
Dec 24, 2019·Human Reproduction Update·Yossi MizrachiAriel Weissman
Mar 21, 2021·Human Reproduction Update·Francisca MartinezNikolaos P Polyzos

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