PMID: 9180103Jun 1, 1997Paper

A prospective, randomized, double-blind multicenter trial of a single bolus injection of the novel modified t-PA E6010 in the treatment of acute myocardial infarction: comparison with native t-PA. E6010 Study Group

Journal of the American College of Cardiology
C KawaiM Nakashima

Abstract

This prospective, randomized, double-blind multicenter trial evaluated the efficacy and safety of a single bolus injection of the novel modified tissue-type plasminogen activator (t-PA) E6010 in the treatment of acute myocardial infarction compared with that of native t-PA. E6010 is a novel modified t-PA with a prolonged half-life (t1/2 alpha > or = 23 min) compared with native t-PA (t1/2 alpha = 4 min). E6010 can be administered in patients as a single intravenous bolus injection, and early recanalization can be expected. The efficacy of E6010 was compared with that of native t-PA in 199 patients with acute myocardial infarction who were treated within 6 h of onset in a prospective, randomized, double-blind multicenter trial. Patients were given either 0.22 mg/kg body weight of E6010 intravenously over 2 min or native t-PA (tisokinase) 28.8 mg or 14.4 million IU (10% of the total dose over 1 to 2 min, the remainder infused over 60 min). The primary end point was the recanalization rate of the infarct-related coronary artery at 60 min after the start of treatment. Time to reperfusion was shorter in the E6010 group than in the native t-PA group. Thrombolysis in Myocardial Infarction flow grade 2 or 3 recanalization at 15, 30, 45...Continue Reading

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Citations

Jun 21, 2002·Circulation Journal : Official Journal of the Japanese Circulation Society·Ken NagaoUNKNOWN FAST Trial
Dec 2, 2008·Circulation Journal : Official Journal of the Japanese Circulation Society·Takeshi YamamotoKeiji Tanaka
Feb 8, 2005·The American Journal of Cardiology·Teruo InoueKoichi Node
Jan 9, 2003·Expert Opinion on Pharmacotherapy·Daniel B McKenzie, Robert G Wilcox
Oct 30, 2016·Bioengineered· Adivitiya, Yogender Pal Khasa
Apr 18, 2002·Neurological Research·Hiromi MuramatsuYasuo Katayama
Apr 23, 2010·Cardiovascular and Interventional Radiology·Takuji YamagamiTsunehiko Nishimura
Jul 11, 2012·The Journal of Pharmacy and Pharmacology·Martin Flemmig, Matthias F Melzig
Jul 20, 2007·The Cochrane Database of Systematic Reviews·M CucheratG Tremeau
Oct 19, 2013·Pediatrics International : Official Journal of the Japan Pediatric Society·Mana HaradaToshiaki Shimizu
Aug 11, 2000·The American Journal of Medicine·M Verstraete

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