A prospective, randomized, double-blind study for the evaluation of assisted hatching in patients with advanced maternal age

Human Reproduction
Susan E LanzendorfS J Muasher

Abstract

The objective of this study was to determine if assisted hatching improved the rates of implantation, clinical pregnancy and ongoing pregnancy for in-vitro fertilization (IVF) patients aged > or =36 years. On the day of oocyte aspiration, consenting patients were randomized according to whether all embryos underwent the hatching procedure (hatched; n = 41) or all embryos remained unhatched (controls; n = 48). Patients in both groups were treated with methylprednisolone and doxycycline starting on the day of oocyte retrieval and continuing for 4 days. The hatching procedure was performed approximately 55 h after insemination on all potential embryos for transfer and employed the release of acidified acid Tyrode's medium against the zona pellucida to create an opening approximately 20 microm in diameter. No significant differences were noted in the mean age, number of oocytes aspirated and number of embryos transferred between the hatched and control groups. In addition, no significant differences were observed in the rates of implantation (11.1 versus 11.3%), clinical pregnancy (39.0 versus 41.7%) and ongoing pregnancy (29.3 versus 35.4%) between the hatched and control groups respectively. These results suggest that assisted ha...Continue Reading

Citations

Nov 3, 2010·Journal of Assisted Reproduction and Genetics·Mohamad Eid HammadehKhaled Refaat Ali
Sep 15, 2004·Fertility and Sterility·UNKNOWN Practice Committee of the American Society for Reproductive Medicine
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Apr 9, 2011·Human Reproduction Update·Wellington P MartinsCarolina O Nastri
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Mar 21, 2013·Reproductive Biology and Endocrinology : RB&E·Chanchai ChailertTeraporn Vutyavanich
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Jan 30, 2019·Fertility and Sterility·Andrea BusnelliEdgardo Somigliana
Feb 2, 2010·Reproductive Biomedicine Online·Mojtaba Rezazadeh ValojerdiBahar Movaghar

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