A Prospective, Randomized, Double-Blinded Trial Comparing Acetaminophen, Ibuprofen, and Oxycodone for Pain Management After Hand Surgery

Orthopedics
Asif M IlyasJonas L Matzon

Abstract

The goal of this study was to evaluate 3 common oral analgesics-oxycodone (OXY), ibuprofen (IBU), and acetaminophen (ACE)-for pain management following carpal tunnel release (CTR) and trigger finger release (TFR) surgery. Outcome measures were pain scores, capsule consumption patterns, and satisfaction. Carpal tunnel or trigger finger patients indicated to undergo primary, unilateral release received 10 capsules of either OXY (5 mg), IBU (600 mg), or ACE (500 mg) postoperatively. Medications were distributed in a randomized fashion, with both surgeons and patients blinded to the selected analgesic. Postoperatively, patients recorded pain level each day using a 0 to 10 visual analog scale, the number of capsules taken each day, and any adverse effects experienced. Medication distribution among the 188 patients completing the study was 62 OXY, 64 IBU, and 62 ACE. Surgical distribution was 76 TFR, 61 endoscopic CTR, and 51 open CTR. Overall, the mean total number of capsules consumed from postoperative days 0 through 5 for OXY, IBU, and ACE was 3.2, 4.0, and 3.1, respectively (P>.05). Mean worst daily pain score for the OXY, IBU, and ACE groups was 2.9, 2.5, and 2.5, respectively (P<.05). On subgroup analyses by procedure type, th...Continue Reading

References

May 29, 2003·The Journal of Hand Surgery·Joy C MacdermidGraham J W King
Jul 25, 2006·Pharmacoepidemiology and Drug Safety·Leonard J PaulozziYongli Xi
Jul 29, 2006·Plastic and Reconstructive Surgery·Christopher J Thomson, Donald H Lalonde
Sep 22, 2006·The Clinical Journal of Pain·Howard G BirnbaumNathaniel P Katz
Jan 18, 2007·JAMA : the Journal of the American Medical Association·Bridget M Kuehn
Jan 6, 2009·Neurology·R GelfmanJ C Stevens
Nov 19, 2010·The New England Journal of Medicine·Susan Okie
Aug 10, 2011·Journal of Opioid Management·Kathryn P AnastassopoulosMyoung S Kim
Aug 23, 2011·Pain·Maria Alexandra Ferreira-ValenteMark P Jensen
Mar 14, 2012·The Journal of Hand Surgery·Jeffrey RodgersEdward Finnerty
Jul 16, 2013·The Journal of Arthroplasty·Joseph D LamplotDavid W Manning
Apr 30, 2014·Clinical Orthopaedics and Related Research·Arjan G J BotDavid Ring
May 9, 2014·Pain Research & Management : the Journal of the Canadian Pain Society = Journal De La Société Canadienne Pour Le Traitement De La Douleur·Chris RingwaltAsheley Cockrell Skinner
Jan 14, 2017·Hand : Official Journal of the American Association for Hand Surgery·Talia ChapmanAsif M Ilyas
Dec 2, 2017·BMJ : British Medical Journal·Michael DavidAndrew Raine

❮ Previous
Next ❯

Citations

Nov 26, 2020·Plastic and Reconstructive Surgery·Jeffrey G StepanDuretti T Fufa
Apr 14, 2021·The Cochrane Database of Systematic Reviews·Mabel Qi He LeowEdwin Sy Chan
May 11, 2021·Journal of the American Academy of Orthopaedic Surgeons. Global Research & Reviews·Jason D YoungGeorge S M Dyer

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.