PMID: 9180105Jun 1, 1997Paper

A prospective, randomized evaluation of prophylactic intraaortic balloon counterpulsation in high risk patients with acute myocardial infarction treated with primary angioplasty. Second Primary Angioplasty in Myocardial Infarction (PAMI-II) Trial Investigators

Journal of the American College of Cardiology
G W StoneC L Grines

Abstract

A large, international, multicenter, prospective, randomized trial was performed to determine the role of prophylactic intraaortic balloon pump (IABP) counterpulsation after primary percutaneous transluminal coronary angioplasty (PTCA) in acute myocardial infarction (AMI). Previous studies have suggested that routine IABP use after primary PTCA reduces infarct-related artery reocclusion, augments myocardial recovery and improves clinical outcomes. Cardiac catheterization was performed in 1,100 patients within 12 h of onset of AMI at 34 clinical centers. Clinical and angiographic variables were used to stratify patients undergoing primary PTCA into high and low risk groups. High risk patients were then randomized to 36 to 48 h of IABP (n = 211) or traditional care (n = 226). The study had 80% power to detect a reduction in the primary end point from 30% to 20%. There was no significant difference in the predefined primary combined end point of death, reinfarction, infarct-related artery reocclusion, stroke or new-onset heart failure or sustained hypotension in patients treated with an IABP versus those treated conservatively (28.9% vs. 29.2%, p = 0.95). The IABP strategy conferred modest benefits in reduction of recurrent ischem...Continue Reading

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Citations

Feb 14, 2014·Current Treatment Options in Cardiovascular Medicine·Jason Hatch, Dmitri Baklanov
Nov 28, 2012·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Uwe ZeymerRalf Zahn
Apr 24, 2012·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Roberto J CubedduIgor F Palacios
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Jul 8, 2008·Lancet·Valbona MirakajPeter Rosenberger
Aug 3, 2006·Journal of Interventional Cardiology·Kishore J HarjaiUNKNOWN Primary Angioplasty In Myocardial Infarction (PAMI) Investigators
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