A Prospective Randomized Study Comparing the Effect of Different Kidney Protection Treatment Protocols on Acute Renal Injury After Extracorporeal Shockwave Lithotripsy

Journal of Endourology
Chi-Fai NgJohn Yuen

Abstract

To perform a prospective study to evaluate the renal protective effects of ramping protocol and pause protocol for extracorporeal shockwave lithotripsy (SWL) in human subjects. Three hundred twenty patients with solitary renal stone <15 mm were randomized to receive one of four protocols: (1) 80% power from beginning until the end of treatment; (2) the first 100 shockwaves (SWs) at 40% power, and then 80% power until the end of treatment; (3) the first 100 shocks at 40% power, followed by a 3-minute pause, and then further SWs at 80% power until the end of treatment; and (4) the first 100 shocks at 80% power, followed by a 3-minute pause, and then further SWs at 80% power until the end of treatment. The primary endpoint was the incidence of renal hematoma assessed by imaging on day 2. Spot urine samples were also collected before and after treatment for acute renal injury marker measurement. The baseline information and treatment parameters of the four groups were comparable. The overall incidence of hematoma formation was 7.69% (24 patients). The number of patients developing hematoma in the four groups was 8 (10.26%), 7 (8.97%), 6 (7.59%), and 3 (3.90%), respectively, and the incidence of hematoma among the four groups was no...Continue Reading

References

Apr 1, 1988·The Journal of Urology·P M KnappR E Steele
Aug 1, 1985·AJR. American Journal of Roentgenology·J V KaudeB Finlayson
Jan 1, 1994·International Urology and Nephrology·J UozumiJ Kumazawa
Feb 3, 2006·Journal of the American Society of Nephrology : JASN·Lynn R WillisJames E Lingeman
Mar 25, 2008·Seminars in Nephrology·James A McAteer, Andrew P Evan
Jan 1, 2013·Journal of Endourology·Hsiang-ying LeeYung-Shun Juan
May 16, 2013·International Urology and Nephrology·Nicholas ObermüllerAnja Urbschat

Citations

Dec 19, 2018·Current Opinion in Urology·Mario Basulto-MartínezJorge Gutiérrez-Aceves
Apr 25, 2019·International Journal of Urology : Official Journal of the Japanese Urological Association·Kazumi TaguchiTakahiro Yasui
Jan 7, 2020·Current Opinion in Urology·Panagiotis MourmourisAndreas Skolarikos
Mar 2, 2017·Current Urology Reports·Andrew C LawlerJustin I Friedlander

Related Concepts

Diastolic Blood Pressure
Treatment Protocols
Hematoma
Kidney
Kidney Calculi
Percutaneous Ultrasonic Lithotripsy
Ureteral Diseases
Body Mass Index Procedure
Urolithiasis
Kidney Failure, Acute

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.