A prospective, randomized study of cryotherapy during administration of high-dose melphalan to decrease the severity and duration of oral mucositis in patients with multiple myeloma undergoing autologous peripheral blood stem cell transplantation

Bone Marrow Transplantation
K LillebyWilliam Bensinger

Abstract

Forty patients with multiple myeloma scheduled to receive melphalan 200 mg/m(2) followed by autologous stem cell transplantation were randomly assigned to receive oral cryotherapy or room temperature normal saline rinses 30 min before and for 6 h after high-dose therapy. Patients were evaluated for the development of mucositis using the National Cancer Institute grading system as well as evaluation of secondary measures such as days of total parenteral nutrition (TPN), narcotic use, hospitalization, weight loss and resumption of oral caloric intake for 28 days after transplant. Patients self-scored their pain, swallowing, drinking, eating, sleeping and taste alterations for 28 days. The primary end point of this trial was the incidence of grades 3-4 mucositis. Compared to the normal saline group, patients using cryotherapy experienced less grade 3-4 mucositis, 14 vs 74%, P=0.0005. Patients receiving cryotherapy also had statistically lower uses of narcotics and TPN, although there were no differences in length of hospitalization or weight loss. Patient-reported pain was significantly lower and activities were significantly better in the cryotherapy group.

Associated Clinical Trials

Oct 25, 2017·Maria Fernanda Setúbal Destro Rodrigues

References

Mar 1, 1991·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D J MahoodN L Gusa
Jun 15, 1996·Lancet·G MeloniF Mandelli
Jan 17, 2004·Seminars in Oncology·Don A GabrielTerrance Comeau
Mar 25, 2004·Seminars in Oncology Nursing·Elenir B C AvritscherLinda S Elting
Dec 17, 2004·The New England Journal of Medicine·Ricardo SpielbergerChristos Emmanouilides
Oct 21, 2005·Clinical Journal of Oncology Nursing·Margaret M Cawley, Laura M Benson
Jul 1, 2004·Journal of the National Comprehensive Cancer Network : JNCCN·William I Bensinger

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Citations

Mar 30, 2007·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Anncarin SvanbergKerstin Ohrn
Jun 11, 2011·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Jan Magnus BjordalRodrigo Ab Lopes-Martins
Sep 21, 2012·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Douglas E PetersonUNKNOWN Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (
Oct 12, 2011·Onkologie·Christoph BusemannWilliam H Krüger
Dec 15, 2010·Future Oncology·Jerry C WuJoseph D Ma
Jul 1, 2010·National Journal of Maxillofacial Surgery·Afshan BeySarwat H Hashmi
Feb 3, 2015·Leukemia & Lymphoma·Adrienne A Phillips, Koen van Besien
Mar 11, 2010·Expert Review of Anticancer Therapy·Pasquale NiscolaTommaso Caravita
Feb 17, 2011·Expert Review of Hematology·Pasquale NiscolaEdoardo Arcuri
Aug 24, 2007·Expert Opinion on Investigational Drugs·Pellegrino Musto, Fiorella D'Auria
Mar 23, 2011·Expert Opinion on Drug Metabolism & Toxicology·Christian WeigeltGuido Kobbe
Jul 14, 2012·Expert Opinion on Biological Therapy·Massimo MartinoAttilio Olivieri
Nov 12, 2013·Journal of Pain and Symptom Management·Kunal C KadakiaCharles L Loprinzi
Aug 9, 2015·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Nina ShahSergio A Giralt
May 5, 2009·Seminars in Oncology Nursing·Chris Rimkus
Oct 22, 2008·Seminars in Oncology·Axel GrotheyUNKNOWN North Central Cancer Treatment Group
Nov 9, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Barry QuinnLena Sharp
Aug 16, 2012·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Muneer H AbidiJoseph Uberti
Mar 13, 2014·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Ajay K NookaEdmund K Waller
Oct 24, 2007·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Yago NietoMilagros Hernández
Nov 16, 2010·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Gordon L PhillipsJonathan W Friedberg
Aug 28, 2012·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Ulas D BayraktarStefan O Ciurea
Jun 11, 2008·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Tanya M WildesSteven M Devine
Sep 17, 2014·European Journal of Oncology Nursing : the Official Journal of European Oncology Nursing Society·Anncarin SvanbergGunnar Birgegård
Nov 28, 2014·Clinical Journal of Oncology Nursing·June EilersLee Ann Johnson
Nov 28, 2013·Clinical Journal of Oncology Nursing·Beth FaimanKathryn Lilleby
May 1, 2016·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Naoto OkadaKeisuke Ishizawa
Oct 11, 2005·Mayo Clinic Proceedings·S Vincent Rajkumar, Robert A Kyle
Dec 20, 2015·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Joey ChenIrina Rajakumar
Nov 17, 2009·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Valkal BhattVivek Roy
Feb 23, 2018·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Java WalladbegiHelen E Colley
Oct 5, 2017·Cancer Chemotherapy and Pharmacology·Java WalladbegiMats Jontell
Dec 24, 2015·The Cochrane Database of Systematic Reviews·Philip RileyMartin G McCabe

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