A prospective randomized trial of a potassium competitive acid blocker vs proton pump inhibitors on the effect of ulcer healing after endoscopic submucosal dissection of gastric neoplasia

The Journal of International Medical Research
Hiroyuki KomoriSumio Watanabe

Abstract

Vonoprazan is a new a potassium-competitive acid blocker (P-CAB) that was recently developed in Japan. However, vonoprazan's efficacy in healing gastric ulcers after endoscopic submucosal dissection (ESD) remains controversial. This study aimed to compare the efficacy of P-CABs and proton pump inhibitors (PPIs) in healing post-ESD ulcers. This prospective randomized controlled trial (UMIN000017386) enrolled 40 patients with gastric neoplasia, who underwent ESD at our hospital from April 2015 to January 2016. Before ESD, patients were randomly divided into the following two groups: group V, vonoprazan 20 mg/day; or group R, rabeprazole 10 mg/day. Medications were taken 1 day before to 4 weeks after ESD. The ESD-induced artificial ulcer size was measured just after ESD and 4 weeks after ESD to calculate the reduction rate as follows: (ulcer area 4 weeks after ESD)/(ulcer area just after ESD) × 100. Eighteen patients in group V and 15 patients in group R were analyzed. The mean reduction rate was significantly different in groups V and R (93.3% vs 96.6%, respectively). Post-ESD bleeding was observed in two patients in group R and drug-induced hepatic injury in one patient in group R. Rabeprazole facilitated the healing process pos...Continue Reading

References

Aug 10, 2000·Alimentary Pharmacology & Therapeutics·C A Stedman, M L Barclay
Nov 1, 2001·Alimentary Pharmacology & Therapeutics·Y HoraiT Ishizaki
Jun 26, 2001·Alimentary Pharmacology & Therapeutics·J P GisbertJ M Pajares
Jul 28, 2005·Chinese Journal of Digestive Diseases·Hiroyuki Ono
Jan 27, 2006·World Journal of Gastroenterology : WJG·Masatsugu ShibaTetsuo Arakawa
Jun 16, 2010·Surgical Endoscopy·Kazuhisa OkadaMasahiro Igarashi
Jun 18, 2010·World Journal of Gastroenterology : WJG·Yosuke TsujiNobuyuki Matsuhashi
Mar 18, 2011·The Journal of Pharmacology and Experimental Therapeutics·Yasunobu HoriNobuhiro Inatomi
Apr 27, 2012·Gastroenterology Research and Practice·Shinichi MukaiToshio Nakanishi
Nov 21, 2014·Journal of Clinical Biochemistry and Nutrition·Kenji FurutaYoshikazu Kinoshita
Mar 7, 2015·Drugs·Karly P Garnock-Jones
Feb 11, 2016·World Journal of Gastrointestinal Endoscopy·Su-Jin KimSu-Bum Park
Mar 19, 2016·Alimentary Pharmacology & Therapeutics·T KagamiT Furuta
Jul 29, 2016·Alimentary Pharmacology & Therapeutics·T KagawaT Inaba
Aug 6, 2016·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Daisuke MaruokaOsamu Yokosuka
Dec 3, 2016·World Journal of Gastrointestinal Endoscopy·Kazuya TakahashiShuji Terai

❮ Previous
Next ❯

Methods Mentioned

BETA
dissection

Software Mentioned

SAS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.