A prospective randomized trial of conventional in vitro fertilization versus intracytoplasmic sperm injection in unexplained infertility.

Journal of Assisted Reproduction and Genetics
Shu C FoongCalvin A Greene

Abstract

To compare outcomes in patients with unexplained infertility undergoing conventional in vitro fertilization (IVF) versus intracytoplasmic sperm injection (ICSI). Sixty women with unexplained infertility in a Canadian tertiary-level clinic were randomized to IVF or ICSI. Subjects underwent downregulation with gonadotropin-releasing hormone agonist prior to initiation of recombinant human follicle-stimulating hormone. The primary outcome measure was fertilization rate. Secondary outcomes included implantation rate, embryo quality, clinical pregnancy rate, and live birth rate. There was no statistically significant difference in fertilization rate (77.2% IVF vs. 82.4% ICSI), implantation rate (38.2% IVF vs. 44.4% ICSI), clinical pregnancy rate (50% in each group), or live birth rate (46.7% IVF vs. 50% ICSI). There were two cases of failed fertilization in the IVF group. There was no significant difference in embryo quality between groups. There were no differences in clinical outcomes associated with IVF versus ICSI in the treatment of unexplained infertility.

References

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Citations

Jul 28, 2011·Journal of Assisted Reproduction and Genetics·Martha LunaAlan B Copperman
Dec 28, 2010·Journal de gynécologie, obstétrique et biologie de la reproduction·A Amar-HoffetJ Belaisch-Allart
Aug 19, 2008·Human Reproduction Update·Anders Nyboe AndersenAnne Loft
Apr 22, 2009·Human Reproduction Update·P DevroeyUNKNOWN Evian Annual Reproduction (EVAR) Workshop Group 2008
Jul 20, 2007·The New England Journal of Medicine·Tarun Jain, Ruchi S Gupta
Feb 24, 2016·Fertility and Sterility·Deidre D Gunn, G Wright Bates
Feb 19, 2008·Journal de gynécologie, obstétrique et biologie de la reproduction·P Barrière
May 6, 2014·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Ju Yeong KimSeok Hyun Kim
Sep 18, 2012·Fertility and Sterility·UNKNOWN Practice Committees of the American Society for Reproductive Medicine and Society for Assisted Reproductive Technology
Jul 17, 2018·BJOG : an International Journal of Obstetrics and Gynaecology·J WilkinsonC M Farquhar
May 30, 2015·Obstetrics & Gynecology Science·Myo Sun KimByung Chul Jee
Jun 13, 2019·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Kylie SustarAlex Polyakov
Apr 18, 2019·Clinical Obstetrics and Gynecology·Joshua D StewartZev Rosenwaks
Jul 4, 2018·Nature Reviews. Urology·Sandro C EstevesPeter Humaidan
Nov 6, 2020·Seminars in Reproductive Medicine·Danni ZhengVinh Q Dang
Nov 26, 2020·Tissue Engineering and Regenerative Medicine·Russel C SequeiraJames J Yoo
Nov 7, 2020·Journal of Assisted Reproduction and Genetics·Mounia HaddadGianpiero D Palermo

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