PMID: 6198367Dec 1, 1983Paper

A prospective randomized trial to compare mezlocillin and metronidazole with cefuroxime and metronidazole as prophylaxis in elective colorectal operations

The Journal of Hospital Infection
N S AmbroseM R Keighley

Abstract

A prospective randomized trial has compared a broad spectrum ureidopenicillin with a broad spectrum cephalosporin for prophylaxis against the aerobic organisms encountered during elective colonic surgery. Even though only two doses of antibiotics were administered the incidence of severe sepsis was low. Severe wound infection occurred in three of the patients receiving mezlocillin and metronidazole (6 per cent) compared with six in the group receiving cefuroxime and metronidazole (13 per cent). Minor wound sepsis was recorded in 24 per cent of patients receiving mezlocillin and metronidazole compared with only 11 per cent after cefuroxime and metronidazole. There were two episodes of septicaemia, one in each group, and three abscesses, all of which occurred in patients receiving metronidazole and mezlocillin. The total number of surgically related infections was, however, significantly less with cefuroxime and metronidazole (N = 13) compared with mezlocillin and metronidazole (N = 23; P less than 0.03). Escherichia coli was the principal organism responsible for surgically-related postoperative sepsis: (22 isolates: 14 mezlocillin and eight cefuroxime) all of which sensitive to the agents used. Pseudomonas aeruginosa was recove...Continue Reading

References

Dec 1, 1981·The Journal of Antimicrobial Chemotherapy·R WiseJ E Allcock

Citations

Mar 1, 1985·The Journal of Hospital Infection·T E Bucknall
Mar 1, 2006·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·David NeufeldRivka Zissin
May 13, 2014·The Cochrane Database of Systematic Reviews·Richard L NelsonMarija Barbateskovic
Feb 1, 1997·The British Journal of Surgery·A W Bradbury, S Barrett
May 19, 2012·Diseases of the Colon and Rectum·Zeiad I HussainDavid Alexander

Related Concepts

Zinacef
Cephalosporanic Acids
Clinical Trials
Clostridium
Taenia Coli
Polychemotherapy
Bayer 5360
Melocin
Premedication
Pseudomonas aeruginosa

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