A prospective, randomized, within-subject study of ALA-PDT for actinic keratoses using different irradiation regimes

Photodermatology, Photoimmunology & Photomedicine
Oscar ZaarJohn Paoli

Abstract

Photodynamic therapy (PDT) can be used to treat large fields of actinic keratoses (AKs) with high clearance rates. A notable downside is the amount of pain that accompany the treatment. This study aimed to optimize the illumination protocol during conventional PDT in order to reduce pain without compromising treatment effectiveness. In this prospective, randomized study with a split-face design, patients with, symmetrically distributed AKs were included. All patients were treated using a ALA 78 mg/g gel. One side was illuminated with the Aktilite® CL-128 lamp and the other side with the RhodoLED® lamp in which the light intensity gradually increased to a maximum of 60%. Both sides received a total light dose of 37 J/cm2 . Pain during the treatment was measured using a visual analogue scale. The clinical effectiveness of the 2 treated sides was assessed after 12 weeks. Twenty-nine patients with 399 AKs were included. Illumination with the gradually increasing light intensity resulted in a decrease in the median visual analogue scale score by 1.1 points. Clearance rates were similar between the 2 lamps. Minimizing the light intensity during the illumination phase of PDT reduces pain, while still preserving a high clearance rate o...Continue Reading

References

Dec 22, 1999·Journal of the American Academy of Dermatology·R G Glogau
May 3, 2003·Journal of Pain and Symptom Management·John T FarrarBrian L Strom
May 10, 2007·The British Journal of Dermatology·J Röwert-HuberE Stockfleth
Feb 21, 2008·The British Journal of Dermatology·S R WiegellH C Wulf
Jun 30, 2010·Photodermatology, Photoimmunology & Photomedicine·Philipp BabilasRolf-Markus Szeimies
May 26, 2011·Acta Dermato-venereologica·Christina B HalldinHelena Gonzalez
Jul 7, 2011·Photodermatology, Photoimmunology & Photomedicine·Zoi ApallaDemetris Ioannides
Jan 4, 2012·Journal of the European Academy of Dermatology and Venereology : JEADV·S R WiegellL R Braathen
Jan 10, 2012·Journal of the European Academy of Dermatology and Venereology : JEADV·L R BraathenR-M Szeimies
Nov 28, 2012·Journal of the European Academy of Dermatology and Venereology : JEADV·C A MortonL R Braathen
Jun 22, 2014·Annales de dermatologie et de vénéréologie·B Tack
Jun 13, 2015·European Journal of Dermatology : EJD·Colin MortonUNKNOWN European Dermatology Forum
Mar 16, 2016·Photodiagnosis and Photodynamic Therapy·Ben NovakHermann Luebbert
Jan 26, 2017·The British Journal of Dermatology·B WangX L Wang

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