A prospective study: inflammation, infection and comorbidity in patients on long-term dialysis

Journal of Renal Care
Türkay AkbaşEmel Akoğlu

Abstract

The goal of this study was to identify inflammatory and infectious markers and their roles in mortality. We enrolled 111 patients on haemodialysis (HD) and collected data at three time points (baseline, 33 and 76 months). Rates of Chlamydophila pneumoniae IgG, CRP ≥3 mg/l, ESR >50 mm/hour and fibrinogen >4 g/l were, respectively, 63.1%, 60.4%, 48.6% and 42.3%. Mortality was 21.6% and 43.2% at 33 and 76 months where 58.3% of all deaths were cardiocerebrovascular (CCV) related. Non-survivors were older than survivors. Univariate analysis showed diabetes mellitus (DM) and cerebrovascular accident (CVA) as important for the 33-month all-cause mortality, and CRPlog , fibrinogen, ESR >50 mm/hour, cardiovascular disease (CVD) and DM for the 76-month all-cause mortality. CVA was meaningful for the 33-month CCV mortality, and CVD, DM and ESR >50 mm/hour for the 76-month CCV mortality. Kaplan-Meier revealed poorer survival for patients with ESR >50 mm/hour at 76 months. Cox regression showed CVD, CVA and age as mortality predictors. Age, CVD and CVA are predictors for mortality in patients on HD patients, but the presence of C. pneumoniae IgG and inflammation are not.

References

Jul 1, 1987·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J BathonM Mayes
Aug 1, 1986·Archives of Internal Medicine·R M Fincher, M I Page
Aug 1, 1995·Kidney International·G A KaysenT A Depner
Nov 1, 1996·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·M BrouillardD Pagniez
May 1, 1997·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·G A KaysenT A Depner
Feb 12, 1998·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·M KochE Ritz
Mar 21, 1998·Kidney International·A R QureshiJ Bergström
Jun 19, 1998·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·S F LeaveyP J Held
Aug 5, 1998·Kidney International·W F Owen, E G Lowrie
Feb 13, 1999·Kidney International·J ZimmermannC Wanner
Aug 26, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·K IsekiK Fukiyama
Feb 29, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J Y YeunG A Kaysen
Apr 15, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M J Sarnak, A S Levey
Jul 8, 2000·Kidney International·A K CheungA S Levey
Mar 29, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·M Haubitz, R Brunkhorst
Jul 31, 2002·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Alessandro Amore, Rosanna Coppo
Jul 9, 2003·Kidney International·Carmine ZoccaliLorenzo Salvatore Malatino
Jul 16, 2003·Journal of Internal Medicine·C ZoccaliM Buemi
Jul 29, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Akihiko KatoAkira Hishida
Feb 29, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Vincenzo PanichiUNKNOWN RISCAVID Study Group

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