A Prospective Study Investigating Prediagnostic Leukocyte Telomere Length and Risk of Developing Rheumatoid Arthritis in Women

The Journal of Rheumatology
Jennifer PrescottKaren H Costenbader

Abstract

To prospectively examine the association between leukocyte telomere length (LTL) and subsequent rheumatoid arthritis (RA) development in women. Using a case-control design nested within the prospective Nurses' Health Study (NHS), NHS II (NHSII), and Women's Health Study (WHS), each validated case of RA with a prediagnostic blood sample was matched to 3 controls by cohort, age, menopausal status, postmenopausal hormone therapy, and blood collection covariates. We measured telomere length in genomic DNA extracted from stored buffy coat samples using quantitative PCR. We used unconditional logistic regression to determine OR and 95% CI, and random-effects metaanalysis to combine study results. In total, we analyzed 296 incident RA cases and 827 matched controls. Mean age of diagnosis among women who developed RA was 60.5 in NHS/NHSII and 61.3 in WHS. Metaanalysis demonstrated that longer prediagnostic LTL was associated with increased RA risk when women in the longest versus shortest LTL tertile were compared (OR 1.51, 95% CI 1.03-2.23, Pheterogeneity = 0.27). However, statistically significant between-study heterogeneity was observed for the intermediate tertile category (Pheterogeneity = 0.008). We did not observe heterogeneity ...Continue Reading

References

Nov 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·R C AllsoppC B Harley
Jun 1, 1992·The Journal of Clinical Investigation·C M WeyandJ J Goronzy
Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
May 1, 1995·The Journal of Clinical Investigation·C M WeyandJ J Goronzy
Aug 2, 2000·Proceedings of the National Academy of Sciences of the United States of America·K KoetzC M Weyand
May 10, 2002·Nucleic Acids Research·Richard M Cawthon
Sep 6, 2002·Proceedings of the National Academy of Sciences of the United States of America·Akio MorinobuJohn J O'Shea
May 16, 2003·Nature·Gary S Firestein
Oct 28, 2003·Proceedings of the National Academy of Sciences of the United States of America·Stefan O SchönlandCornelia M Weyand
Aug 4, 2004·Autoimmunity Reviews·Eric Boren, M Eric Gershwin
Oct 14, 2004·Annals of the Rheumatic Diseases·L KlareskogL Padyukov
Jul 7, 2005·JAMA : the Journal of the American Medical Association·Nancy R CookJulie E Buring
Jul 7, 2005·JAMA : the Journal of the American Medical Association·I-Min LeeJulie E Buring
Aug 23, 2005·Lancet·A M ValdesT D Spector
Jan 25, 2006·Autoimmunity Reviews·Martina Prelog
Nov 23, 2006·Annals of the Rheumatic Diseases·Sophia E SteerTim D Spector
May 30, 2007·Experimental Hematology·Thomas A WidmannMichael Pfreundschuh
Nov 30, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Hao WangAlberto Ascherio
Mar 4, 2008·Arthritis and Rheumatism·Brian WalittUNKNOWN Women's Health Initiative Investigators
Aug 1, 2008·The Journal of Investigative Dermatology·Jiali HanImmaculata De Vivo
Dec 6, 2008·American Journal of Epidemiology·Abraham AvivGerald S Berenson
Feb 17, 2009·Clinica Chimica Acta; International Journal of Clinical Chemistry·Robert Y L ZeePaul M Ridker
Feb 28, 2009·Arthritis and Rheumatism·Elizabeth W KarlsonKaren H Costenbader
Mar 24, 2009·Aging Cell·Ana V Diez RouxTeresa Seeman
Nov 26, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Qing LanNathaniel Rothman
Apr 10, 2010·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Shradha Agarwal, Paula J Busse
Sep 10, 2011·Aging Cell·Emma L B Barrett, David S Richardson
Nov 29, 2011·Autoimmunity Reviews·Lisa R Sammaritano
Oct 31, 2012·American Journal of Nephrology·Nisha BansalChi-Yuan Hsu
Apr 29, 2014·International Journal of Cancer. Journal International Du Cancer·Fatemeh Saberi HosnijehRoel Vermeulen

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