PMID: 8948307Nov 1, 1996Paper

A prospective study of 287 patients with polymyalgia rheumatica and temporal arteritis: clinical and laboratory manifestations at onset of disease and at the time of diagnosis

British Journal of Rheumatology
G Myklebust, J T Gran

Abstract

A prospective study of 287 patients with giant cell arteritis (GCA), including polymyalgia rheumatica (PMR) and temporal arteritis (TA), was conducted during 1987-1994. All patients were evaluated prior to the start of drug treatment. During the same period, 31 patients with GCA, of whom 12 cases had TA, were admitted to other departments in the hospital. At onset of disease, all patients were > or = 50 yr of age. Peripheral arthritis was found in 24.4% of patients with PMR, while none of the patients with TA exhibited such manifestations. Clinical features at onset of disease differed from those appearing at presentation to the hospital. Thus, the gradual development of a full-blown clinical picture may be responsible for the delay in diagnosis of GCA. The majority of cases (80%) presented with "pure' PMR without clinical signs or symptoms of concomitant TA. In a random sample of 68 patients with "pure' PMR, histological examinations of biopsy specimens of the temporal artery revealed inflammatory changes in three patients only (4.4%). Consequently, arterial biopsy in patients with clinical features of PMR only, appears to be unnecessary. Among patients with TA referred to the department of internal medicine, general malaise, ...Continue Reading

Citations

Jan 23, 2009·Zeitschrift für Rheumatologie·P Vaith, K Warnatz
Dec 30, 2011·Current Neurology and Neuroscience Reports·Tanaz A Kermani, Kenneth J Warrington
Mar 18, 2003·Joint, Bone, Spine : Revue Du Rhumatisme·Javier NarváezD Roig-Escofet
Sep 21, 2013·Eye·S L LevyA R Nestel
Jun 19, 2008·Journal of General Internal Medicine·Serge De GolovineLee Lu
Oct 16, 2014·Autoimmunity Reviews·Khalil BourjiLeonardo Punzi
May 13, 2014·Rheumatology International·Ediz DalkılıçMustafa Yurtkuran
Jun 30, 2009·Der Internist·L Caspary, S Schellong
Sep 15, 2015·Expert Review of Clinical Immunology·F David CarmonaMiguel A González-Gay
Nov 24, 1999·Scandinavian Journal of Rheumatology·J T Gran
Mar 15, 2003·Scandinavian Journal of Rheumatology·Geirmund MyklebustJan Tore Gran
Jul 28, 2013·The Surgical Clinics of North America·William Wu, Rabih A Chaer
Mar 27, 2013·La Revue de médecine interne·K-H LyE Vidal
Jul 13, 2002·Arthritis and Rheumatism·Gary S HoffmanUNKNOWN International Network for the Study of Systemic Vasculitides
Nov 29, 2011·Seminars in Arthritis and Rheumatism·Tanaz A KermaniKenneth J Warrington
Aug 10, 2011·Physical Medicine and Rehabilitation Clinics of North America·Elana M ObersteinAviva Hopkins
May 12, 2010·Autoimmunity Reviews·Kim-Heang LyLuc Mouthon
Jan 28, 2005·Journal of the American Geriatrics Society·Enrique Antón
Jun 10, 2004·Headache·Pietro CortelliUNKNOWN Multidisciplinary Group for Nontraumatic Headache in the Emergency Department
Jan 1, 2009·Arthritis and Rheumatism·Arathi R Setty, Dwight Robinson
Jul 22, 2014·Headache·Jonathan H Smith, Jerry W Swanson
Aug 4, 2004·Joint, Bone, Spine : Revue Du Rhumatisme·Leonardo Punzi, Corrado Betterle
Mar 16, 2007·Seminars in Arthritis and Rheumatism·Javier NarváezJosé Valverde
Jul 17, 2015·International Journal of Rheumatic Diseases·Abhijeet Danve, James O'Dell
Oct 12, 2012·Lancet·Tanaz A Kermani, Kenneth J Warrington
May 21, 2013·Scandinavian Journal of Rheumatology·K GroßeN T Baerlecken
Jun 3, 2015·Clinical Medicine : Journal of the Royal College of Physicians of London·James Galloway, Andrew P Cope
Apr 22, 2015·Current Neurology and Neuroscience Reports·Thomas P Bravo
Jul 22, 2008·Journal of Vascular Surgery·Stan P JanssenYvo M Smulders
Apr 16, 2016·Expert Review of Clinical Immunology·Francesco MuratoreCarlo Salvarani
Jul 8, 2016·Scandinavian Journal of Rheumatology·N NaderiC Turesson
Nov 30, 2016·Experimental Biology and Medicine·Francesca OmettoAndrea Doria
May 13, 2017·Expert Opinion on Therapeutic Targets·Judith AustermannJohannes Roth

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.