PMID: 15233411Jul 6, 2004Paper

A prospective study of adherence to glatiramer acetate in individuals with multiple sclerosis

The Journal of Neuroscience Nursing : Journal of the American Association of Neuroscience Nurses
C FraserTimothy Vollmer

Abstract

The purpose of this prospective study was to investigate whether self-efficacy, hope, level of disability, perceived support, and previous use of an immunomodulatory therapy when measured at the initiation of a therapy can accurately predict adherence. A convenience sample included 108 individuals with multiple sclerosis who initiated therapy with glatiramer acetate (Copaxone), plus or minus 21 days, and completed instruments online that included the Multiple Sclerosis Self-Efficacy Scale (MSSE), the Herth Hope Index, Performance Scales, and a sociodemographic data sheet that included questions about previous use of immunomodulators and individuals considered most supportive of glatiramer acetate therapy. Logistic regression analysis revealed that the MSSE total (Control and Function subscales combined) was the only significant predictor of adherence. The higher the score, the more likely the individual was to adhere to glatiramer acetate. Those in the adherent group had a significantly greater level of self-efficacy. The MSSE measured at the initiation of glatiramer acetate therapy correctly classified 98.8% of those who were adherent at the 6-month follow-up. For each unit of increase in score, the likelihood of adherence inc...Continue Reading

Associated Clinical Trials

Citations

Mar 13, 2008·Der Nervenarzt·S KernT Ziemssen
Mar 28, 2009·Journal of Neurology·Thomas Klauer, Uwe K Zettl
Feb 4, 2010·Journal of Behavioral Medicine·Jared M BruceSharon Lynch
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Jan 1, 2012·Journal of Central Nervous System Disease·Oscar Fernández
Feb 6, 2018·Therapeutic Advances in Neurological Disorders·Veit BeckerTjalf Ziemssen
May 5, 2007·The Journal of Neuroscience Nursing : Journal of the American Association of Neuroscience Nurses·Cira Fraser, Sue Polito
Nov 6, 2010·The Journal of Neuroscience Nursing : Journal of the American Association of Neuroscience Nurses·Christina CaonJennifer Shoemaker
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Mar 10, 2017·Multiple Sclerosis : Clinical and Laboratory Research·Carolyn E SchwartzE Ann Yeh
Jul 9, 2021·Patient Preference and Adherence·Gabriele Helga FrankeTino Prell

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