A prospective study of cancer survivors and risk of sepsis within the REGARDS cohort

Cancer Epidemiology
J X MooreRussell L Griffin

Abstract

Hospitalized cancer patients are nearly 10 times more likely to develop sepsis when compared to patients with no cancer history. We compared the risk of sepsis between cancer survivors and no cancer history participants, and examined whether race was an effect modifier. We performed a prospective analysis of data from the REasons for Geographic and Racial Differences in Stroke (REGARDS) cohort. We categorized participants as "cancer survivors" or "no cancer history" derived from self-reported responses of being diagnosed with any cancer, excluding non-melanoma skin cancer. We defined sepsis as hospitalization for a serious infection with ≥2 systemic inflammatory response syndrome criteria. We performed Cox proportional hazard models to examine the risk of sepsis after cancer (adjusted for sociodemographics, health behaviors, and comorbidities), and stratified by race. Among 29,693 eligible participants, 2959 (9.97%) were cancer survivors, and 26,734 (90.03%) were no cancer history participants. Among 1393 sepsis events, the risk of sepsis was higher for cancer survivors (adjusted HR: 2.61, 95% CI: 2.29-2.98) when compared to no cancer history participants. Risk of sepsis after cancer survivorship was similar for Black and White...Continue Reading

Citations

Apr 16, 2020·BMC Cancer·Himanshu TripathiSaroj Kant Mohapatra
Jun 28, 2019·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Fabrice CamouNahéma Issa
Aug 10, 2020·Shock·Yibing WeiDaniel Remick
Mar 17, 2021·Seminars in Oncology Nursing·Aran Tavakoli, Alia Carannante
Jul 2, 2021·American Journal of Critical Care : an Official Publication, American Association of Critical-Care Nurses·Michael A LiuChien-Chang Lee
Sep 22, 2021·CA: a Cancer Journal for Clinicians·Amila K NanayakkaraDavid E Greenberg
Nov 25, 2021·Asia-Pacific Journal of Clinical Oncology·Man-Yee ManMei-Wan Yeung

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