A prospective study of coronary heart disease in relation to fasting insulin, glucose, and diabetes. The Atherosclerosis Risk in Communities (ARIC) Study

Diabetes Care
A R FolsomJ H Eckfeldt

Abstract

To determine the association of coronary heart disease (CHD) incidence with diabetes, fasting serum glucose, and insulin in a biracial cohort of middle-aged men and women. We examined a population-based sample (n = 13,446 free of baseline CHD) from four U.S. communities in 1987-1989. We defined diabetes on the basis of baseline fasting glucose concentration (> or = 7.8 mmol/l), medical history, and current medications. A central laboratory measured fasting insulin with a nonspecific radioimmunoassay. After 4-7 years, 209 men and 96 women developed CHD. After adjustment for sociodemographic characteristics, smoking status, ethanol intake, sports participation, and hormone replacement therapy, the relative risk of CHD for people with diabetes versus those without diabetes was 3.45 (95% CI 2.16-5.50) among women and 2.52 (1.78-3.56) among men. Relative risks of CHD with diabetes were somewhat lower in blacks than non-blacks, but because diabetes was more than twice as prevalent in blacks, the percentage of CHD cases attributable to diabetes (population attributable risk) was 27% for black women, 15% for non-black women, 8% for black men, and 12% for non-black men. Among people without diabetes, fasting glucose was not independentl...Continue Reading

Citations

Aug 9, 2012·JAMA : the Journal of the American Medical Association·Mercedes R CarnethonAlan R Dyer
May 8, 2002·Diabetes/metabolism Research and Reviews·Maureen I HarrisMark S Eberhardt
Jan 13, 2005·Diabetologia·C MeisingerUNKNOWN MONICA/KORA Augsburg Cohort Study
Apr 5, 2002·Current Atherosclerosis Reports·Braxton D Mitchell, Ikhide G Imumorin
Jun 30, 2004·Diabetes Research and Clinical Practice·David W BrownUNKNOWN behavioral risk factor surveillance system (BRFSS)
Mar 1, 2005·European Journal of Internal Medicine·J R TimmerF Zijlstra
Feb 13, 2004·Progress in Cardiovascular Diseases·Suzanne R Steinbaum
Jul 19, 2003·Metabolism: Clinical and Experimental·C J GlueckLuann Sieve-Smith
Mar 29, 2003·Mechanisms of Ageing and Development·Karen E Remsberg, Roger M Siervogel
Jun 14, 2003·Current Problems in Cardiology·John M FlackSamar A Nasser
Sep 24, 2002·International Journal of Cardiology·Altan OnatGülay Hergenç
Nov 18, 2000·Diabetes Research and Clinical Practice·J B BrownM Aickin
Feb 2, 2002·British Journal of Community Nursing·G Nelson
Sep 25, 2003·Journal of Clinical Epidemiology·Lloyd E ChamblessF Javier Nieto
Sep 5, 2003·Journal of Diabetes and Its Complications·Ferran Rius RiuAnna Sanmartí Sala
Jul 19, 2006·Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association·Edward C Suarez
Dec 8, 2011·European Journal of Clinical Nutrition·K J SmithA J Venn
Jul 25, 2000·European Journal of Clinical Investigation·A Martínez-RubioJ O Llanos
Mar 5, 2002·Diabetic Medicine : a Journal of the British Diabetic Association·L BokemarkUNKNOWN Atherosclerosis and Insulin Resistance sstudy (AIR)
Jun 13, 2002·Diabetic Medicine : a Journal of the British Diabetic Association·B HedbladL Janzon
Aug 25, 2001·The British Journal of Nutrition·F BrancaH Verhagen
Mar 13, 2009·Human Reproduction Update·Lisa Moran, Helena Teede
Oct 2, 2003·The Journal of Cardiovascular Nursing·Deborah A ChyunGail D Melkus
Mar 21, 1998·Current Opinion in Lipidology·F W Hanna
Dec 8, 2007·Stroke; a Journal of Cerebral Circulation·Bernadette Boden-AlbalaMyunghee C Paik
May 5, 2004·Journal of Community Health Nursing·Robin WhittemoreMargaret Grey
May 10, 2006·Clinical Chemistry and Laboratory Medicine : CCLM·Marco Orsini FedericiUNKNOWN Italian Society of Laboratory Medicine
Nov 8, 2005·International Heart Journal·Aziz KarabulutYasin Aksu
Sep 17, 2010·Srpski arhiv za celokupno lekarstvo·Biljana ParapidMiodrag Ostojić
Jan 12, 2008·Journal of Clinical Biochemistry and Nutrition·Shoko KuriyamaHisataka Moriwaki
Jul 3, 2010·Journal of Atherosclerosis and Thrombosis·Muhei TanakaNaoto Nakamura
Mar 8, 2014·Medicina clínica·Lara Albert Fàbregas, José Miguel González-Clemente
Dec 2, 2011·Journal of Nutrition and Metabolism·Delphine Fradin, Pierre Bougnères
Apr 14, 2005·Dimensions of Critical Care Nursing : DCCN·Jennifer Saylor

❮ Previous
Next ❯

Related Concepts

Related Feeds

American Diabetes Association Journals

Discover the latest diabetes research published by the journals from the American Diabetes Association.