A prospective study of estrogen replacement therapy and the risk of developing Alzheimer's disease: the Baltimore Longitudinal Study of Aging

Neurology
C KawasE Metter

Abstract

Previous reports have suggested that estrogen replacement therapy (ERT) in women may exert a protective effect on their risk of developing Alzheimer's disease (AD). We investigated this relationship in the Baltimore Longitudinal Study of Aging (BLSA), a prospective multidisciplinary study of normal aging conducted by the National Institute on Aging. The sample consisted of 472 post- or perimenopausal women followed for up to 16 years in the BLSA. We documented ERT prospectively at each BLSA visit, and we categorized women who had used oral or transdermal estrogens at anytime as ERT users. We used Cox proportional hazards models with time-dependent covariates to estimate the relative risk of developing AD after ERT as compared with women who had not used estrogen replacement. Approximately 45% of the women in the cohort had used ERT, and we diagnosed 34 incident cases of AD (NINCDS/ADRDA criteria) during follow-up, including nine estrogen users. After adjusting for education, the relative risk for AD in ERT users as compared with nonusers was 0.46 (95% CI, 0.209-0.997), indicating a reduced risk of AD for women who had reported the use of estrogen. Our data did not show an effect for duration of ERT usage. Our finding offers add...Continue Reading

Associated Clinical Trials

Citations

Dec 5, 2000·Movement Disorders : Official Journal of the Movement Disorder Society·H H Fernandez, K L Lapane
Dec 18, 2001·The Journal of Comparative Neurology·Z LiuV E Koliatsos
Jul 12, 2002·Journal of Neuroscience Research·Sophie E PingGraham L Barrett
Oct 23, 2002·Journal of Neuroscience Research·Bruce Teter, J Wesson Ashford
Oct 23, 2002·Journal of Neuroscience Research·Richard L BowenCraig S Atwood
Dec 6, 2011·Age·James A YonkerCraig S Atwood
Aug 10, 2002·Current Neurology and Neuroscience Reports·Mary Sano
Aug 25, 2004·Current Neurology and Neuroscience Reports·Ruth A MulnardClaudia H Kawas
Apr 11, 2003·Current Treatment Options in Cardiovascular Medicine·Svati H. Shah, Karen P. Alexander
Sep 6, 2002·Journal of Molecular Neuroscience : MN·Barbara B Sherwin
Nov 16, 2012·Journal of Biosciences·V KaliyamurthiG Victor Rajamanickam
Jun 18, 2005·Neurobiology of Aging·Gregory J BrewerRoberta D Brinton
Jan 27, 2004·NeuroImage·Jamie L EberlingWilliam J Jagust
Nov 19, 2003·Neuroscience·M RamsdenC J Pike
Dec 29, 2000·Disease-a-month : DM·D S Knopman
Nov 15, 2000·Disease-a-month : DM·D A Bennett
Oct 10, 2001·Fertility and Sterility·Y R Smith, J K Zubieta
Feb 8, 2003·Journal of Psychosomatic Research·Laura H Coker, Sally A Shumaker
Dec 14, 1999·Journal of the Neurological Sciences·S A Rudnicki
Nov 7, 2002·Physiology & Behavior·Ann-Charlotte E GranholmLinda S Crnic
Jun 1, 2002·Ageing Research Reviews·Jerald S Goldstein, Cynthia K Sites
Sep 18, 1997·Lancet·J E Compston
Mar 21, 2003·Journal of Affective Disorders·Meir SteinerLeslie Born
May 22, 1998·Trends in Genetics : TIG·P S Moore, Y Chang
Aug 23, 2002·Brain Research. Molecular Brain Research·Melinda E WilsonPhyllis M Wise
Jul 11, 2002·Brain Research. Molecular Brain Research·Pamela J McMillanDaniel M Dorsa

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Aging Epidemiology

This feed focuses on epidemiology of aging and aging-related conditions, including Alzheimer’s disease, dementia, and age-associated cognitive impairment. Here is the latest research.