A prospective study of hearing changes after beginning zidovudine or didanosine in HIV-1 treatment-naïve people

BMC Infectious Diseases
Jeffrey T SchoutenChristina M Marra

Abstract

While hearing loss in HIV-infected people after beginning nucleoside reverse transcriptase inhibitors (NRTIs) has been reported, there have been no prospective studies that measured hearing changes longitudinally in treatment-naïve HIV-infected subjects following initiation of regimens containing NRTIs. The goal of this study was to conduct a prospective assessment of the contribution of zidovudine (ZDV) and didanosine (ddI) to hearing loss. A prospective observational pilot study to determine whether ZDV or ddI, alone or in combination, are associated with sensorineural hearing loss in HIV-infected persons. Changes in hearing levels at all frequencies and in low and high frequency pure tone averages were measured at baseline, 16, and 32 weeks after initiating antiretroviral therapy. Treatment with ZDV and ddI did not result in loss of hearing, even after taking into account noise exposure, immune status and age. The results of this prospective pilot study do not support the notion that treatment with nucleoside antiretrovirals damages hearing.

References

Apr 1, 1997·Archives of Neurology·C M MarraG A Gates
May 8, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J SimdonE Connick
Nov 17, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·B Williams
Dec 26, 2001·Archives of Otolaryngology--head & Neck Surgery·A Mudry
Jan 5, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D ReyJ M Lang
Feb 25, 2003·The Journal of the Acoustical Society of America·Mary M PrinceLeslie T Stayner

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Citations

Dec 24, 2013·CNS Drugs·Michael S AbersJoseph S Kass
Dec 1, 2011·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Christina K ChaoJoseph R Zunt
Mar 25, 2011·Journal of Pharmacy & Bioallied Sciences·Katijah Khoza-Shangase
Oct 10, 2012·International Journal of Audiology·Yolandé van der WesthuizenLouis Murray Hofmeyr
Aug 24, 2016·PloS One·Susan HrapcakSaeed Ahmed
Apr 4, 2008·Hearing Research·Devrim BektasBrenda L Lonsbury-Martin
Jul 27, 2012·Jornal Da Sociedade Brasileira De Fonoaudiologia·Eliene da Silva AraújoKátia de Freitas Alvarenga
Mar 15, 2014·CoDAS·Ana Karina Lima BuritiLilian Ferreira Muniz
Aug 1, 2014·Trends in Hearing·Brandon E CohenPamela C Roehm
Oct 28, 2017·Tropical Medicine & International Health : TM & IH·Robbert J H Ensink, Hannah Kuper
Apr 1, 2010·African Journal of AIDS Research : AJAR·Katijah Khoza-Shangase
Aug 19, 2016·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Glenn J Treisman, Olivia Soudry
Mar 5, 2020·The South African Journal of Communication Disorders. Die Suid-Afrikaanse Tydskrif Vir Kommunikasieafwykings·Alison MillarAlida Naude
Dec 29, 2018·The Laryngoscope·Hailey TheeuwenJamie R Litvack
Nov 22, 2017·Tropical Medicine & International Health : TM & IH·Ruramayi RukuniRashida A Ferrand

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Methods Mentioned

BETA
PCR

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