Abstract
There have been few prospective studies of hepatitis C virus (HCV) infection after needlestick accidents in hospital employees. In the present study, the prevalence and features of HCV infection after needlestick accidents were evaluated prospectively measuring serum HCV-RNA. Subjects were 56 employees who had HCV needlestick accidents. To monitor the development of hepatitis, the serum ALT levels and HCV-related seromarkers, such as first generation anti-HCV (RIA), second generation anti-HCV (PHA) and HCV-RNA (RT-PCR) were measured every month for at least 12 months after the accidents. Three of 56 (5.4%) recipients developed HCV infection. HCV-RNA was detected in all three recipients within 4 months after the exposure, and second-generation HCV antibody was detected in two of three recipients. The detection of HCV-RNA was earlier than that of HCV antibody. Two of three HCV-infected recipients developed type C acute hepatitis and one of two received interferon therapy; however, the other case received no medication. The detection of HCV-related seromarkers and the elevation of ALT levels were transient in these three recipients: thus, none developed chronic hepatitis. In conclusion, HCV infection developed in 5.4% of recipient...Continue Reading
References
Mar 1, 1978·Annals of Internal Medicine·L B SeeffD S Zimmon
Oct 1, 1977·The Journal of Infectious Diseases·T ShikataY Moritsugu
Mar 1, 1992·The Journal of General Virology·H OkamotoY Miyakawa
Apr 6, 1991·Lancet·E CarianiA R Zanetti
Oct 12, 1991·Lancet·M OmataM Ohto
Sep 1, 1991·Annals of Internal Medicine·K KiyosawaH J Alter
Nov 24, 1990·Lancet·A VaqliaF de Lalla
Jan 1, 1990·Scandinavian Journal of Infectious Diseases·U SchlipköterF Deinhardt
Nov 1, 1990·The Journal of Clinical Investigation·P P UlrichG N Vyas
Apr 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·G GillilandH F Bunn
Dec 1, 1987·American Journal of Infection Control·M F Mayo-Smith
May 24, 1980·Lancet·J AntoneJ Maynard
Jun 1, 1982·The Journal of Infectious Diseases·M J AlterG M Matanoski
Apr 30, 1993·Biochemical and Biophysical Research Communications·N KatoM Omata
Citations
Apr 20, 2001·Laboratory Investigation; a Journal of Technical Methods and Pathology·A KnöllW Jilg
Jul 15, 2003·Clinical Microbiology Reviews·David K Henderson
Feb 11, 2004·The Journal of General Virology·Arthur LöveAnders Widell
Oct 19, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Y YazdanpanahE Bouvet
Apr 6, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Chen-Hua LiuDing-Shinn Chen
Feb 10, 2009·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Norbert H GruenerMaria-Christina Jung
Dec 24, 1997·Australian and New Zealand Journal of Medicine·J W Quin
Dec 22, 2006·European Journal of Clinical Investigation·A KubitschkeH Wedemeyer
Mar 6, 2002·Journal of Viral Hepatitis·M I Memon, M A Memon
Feb 13, 2001·ANZ Journal of Surgery·A J Chambers, R S Lord
Aug 9, 2007·Der Internist·A KubitschkeH Wedemeyer
Nov 5, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Susanna NaggieDavid L Thomas
Jun 17, 2016·Current Opinion in Infectious Diseases·Heather Y Hughes, David K Henderson
Nov 12, 2005·Journal of Occupational and Environmental Medicine·Gary RischitelliLinda McCauley
Mar 17, 2007·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Haruhiko NukayaMasashi Mizokami
Nov 3, 2020·The Journal of Craniofacial Surgery·Selim G GebranFan Liang
Feb 4, 2010·Clinics in Liver Disease·Angela Michelin, David K Henderson