A prospective study of leisure-time physical activity and risk of incident epithelial ovarian cancer: Impact by menopausal status

International Journal of Cancer. Journal International Du Cancer
Tianyi HuangShelley S Tworoger

Abstract

Despite multiple hypotheses for a protective effect, epidemiologic findings are inconsistent regarding the association between physical activity and risk of ovarian cancer. Considering physical activity assessment at different times of life, including pre- and postmenopause, may be important for explaining these discrepancies. Therefore, we examined the risk of ovarian cancer according to total, premenopausal and postmenopausal physical activity among 85,462 women from the Nurses' Health Study and 112,679 women from the Nurses' Health Study II. Leisure-time physical activity was prospectively assessed about every 2-4 years using validated questionnaires, and characterized as metabolic equivalent task hours per week (MET-hr/week), which combines exercise duration and intensity. Multivariable Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for these associations. We identified 815 incident epithelial ovarian cancer cases during 24 years of follow-up. A modestly increased ovarian cancer risk was observed for high levels of total cumulative average physical activity and a suggestively increased risk for low activity. Compared to 3-9 MET-hr/week, HRs (95% CIs) were 1.26 (1...Continue Reading

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May 17, 2019·Medicine and Science in Sports and Exercise·Anne McTiernanUNKNOWN 2018 PHYSICAL ACTIVITY GUIDELINES ADVISORY COMMITTEE*
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Sep 3, 2016·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Tianyi HuangElizabeth M Poole
Mar 12, 2021·Cancer Medicine·Andrea L BurasShelley S Tworoger
Mar 4, 2021·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Naoko SasamotoHolly R Harris
May 9, 2021·International Journal of Cancer. Journal International Du Cancer·Tianyi WangShelley S Tworoger
Aug 17, 2021·International Journal of Cancer. Journal International Du Cancer·Tianyi WangShelley S Tworoger

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