A prospective study of mitochondrial DNA copy number and risk of non-Hodgkin lymphoma.

Blood
Qing LanNathaniel Rothman

Abstract

Mitochondrial DNA (mtDNA) copy number is increased in patients with chronic lymphocytic leukemia (CLL), in Burkitt lymphoma and Epstein-Barr virus-transformed lymphoblastoid cell lines, and in T cells activated via the T-cell receptor. We hypothesized that having a higher mtDNA copy number in peripheral white blood cell DNA from healthy subjects would be associated with future risk of non-Hodgkin lymphoma (NHL). We analyzed mtDNA copy number in 104 incident male NHL cases and 104 matched controls within the prospective Alpha-Tocopherol, Beta-Carotene (ATBC) Cancer Prevention cohort. There was a dose-response relationship between tertiles of mtDNA copy number and risk of NHL (odds ratio [OR], 95% confidence interval [CI]: 1.0; 1.4 [0.7-2.8]; and 2.4 [1.0-5.5], respectively; P(trend) = .046). The effect was most pronounced for the CLL/small lymphocytic lymphoma (SLL) subtype (OR: 1.0; 3.2 [0.7-15.7]; 14.1 [1.9-103.2]; P(trend) = .009). These results suggest that mtDNA copy number could be associated with the risk of NHL, particularly CLL/SLL.

References

Jan 1, 1984·Annual Review of Biochemistry·D A Clayton
Nov 5, 1997·The Journal of Biological Chemistry·D L Croteau, V A Bohr
Apr 28, 2005·International Journal of Cancer. Journal International Du Cancer·Elizabeth MamboDavid Sidransky
Jan 11, 2007·Cancer Research·Mukesh VermaKeshav K Singh
May 16, 2008·Environmental and Molecular Mutagenesis·Min ShenQing Lan

❮ Previous
Next ❯

Citations

Jul 26, 2011·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Linda M LiaoWong-Ho Chow
Jul 13, 2012·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Bharat ThyagarajanJian-Min Yuan
May 6, 2011·Cancer Prevention Research·Aditi ChatterjeeDavid Sidransky
Aug 24, 2011·Cancer Prevention Research·Shannon M LynchRachael Z Stolzenberg-Solomon
Oct 19, 2011·Environmental Health Perspectives·Michele CarugnoAndrea Baccarelli
Jun 19, 2013·PloS One·Bharat ThyagarajanJian-Min Yuan
Aug 24, 2013·International Journal of Molecular Sciences·Sylwester GlowackiJanusz Blasiak
Oct 23, 2012·Mitochondrion·Afshan N Malik, Anna Czajka
Dec 9, 2015·Leukemia & Lymphoma·Uri RozovskiZeev Estrov
May 20, 2015·International Journal of Molecular Sciences·Lin Ding, Yilun Liu
Dec 5, 2012·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Daniele CampaFederico Canzian
Jan 13, 2016·Molecular Carcinogenesis·Jie ShenHua Zhao
Dec 29, 2015·Annals of Laboratory Medicine·Min-Gu KangMyung-Geun Shin
Oct 1, 2009·Mitochondrion·Jie ShenHua Zhao
Aug 12, 2014·Molecular Carcinogenesis·Rick J JansenCarlos A Torres-Ramos
Oct 9, 2015·Genetic Testing and Molecular Biomarkers·Doaa I HashadPerihan E Salem
Aug 11, 2015·Molecular Carcinogenesis·Bharat ThyagarajanRoberd M Bostick
Jul 11, 2012·The International Journal of Biochemistry & Cell Biology·Caroline Jose, Rodrigue Rossignol
Nov 8, 2011·The American Journal of Pathology·Dong Kyun WooGerald S Shadel
Oct 27, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Manish KumarRosy Mondal

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.