PMID: 9529184Apr 7, 1998Paper

A prospective study of omeprazole suspension to prevent clinically significant gastrointestinal bleeding from stress ulcers in mechanically ventilated trauma patients

The Journal of Trauma
M R LaskyJ O Phillips

Abstract

To prospectively evaluate the incidence of clinically significant bleeding, side effects, and cost of therapy in mechanically ventilated trauma patients at high risk for stress ulcers who received simplified omeprazole suspension (SOS). Prospective, evaluative study in a Level I trauma center. Mechanically ventilated trauma patients admitted with at least one additional risk factor for stress ulcer development received SOS for stress ulcer prophylaxis. Sixty trauma patients were enrolled. The mean Injury Severity Score was 27.3. After starting SOS, there were no cases of clinically significant upper gastrointestinal bleeding related to stress ulceration. Baseline pH was 3.3, and mean gastric pH after SOS was increased to 6.7 (p < 0.005). There were no adverse effects thought to be related to omeprazole suspension. Incidence of nosocomial pneumonia after beginning SOS was 28.3%. The cost of acquisition plus administration of SOS was $13.13 per day, whereas the cost of drug acquisition alone was $3.83 per day. In a prospective, evaluative study of 60 trauma patients who required mechanical ventilation and had at least one additional risk factor for stress ulcer development, omeprazole suspension prevented clinically significant g...Continue Reading

References

Jan 1, 1992·Scandinavian Journal of Gastroenterology. Supplement·C H Wilder-Smith, H S Merki
Jun 15, 1991·Annals of Internal Medicine·T G Cantú, J S Korek
Jul 1, 1991·Critical Care Medicine·R C Bone
Mar 1, 1991·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·T VialJ Descotes
Jun 1, 1988·American Journal of Infection Control·J S GarnerJ M Hughes
Sep 1, 1985·Gastroenterology·M J OstroK N Jeejeebhoy
Jan 1, 1984·American Journal of Surgery·G M LarsonJ D Richardson
Mar 1, 1981·World Journal of Surgery·H J Priebe, J J Skillman
Jan 1, 1982·Annals of Internal Medicine·S A Finkler
Sep 1, 1994·The Annals of Pharmacotherapy·M A Smythe, B J Zarowitz
May 1, 1994·Intensive Care Medicine·M Tryba
Mar 1, 1996·Digestive Diseases and Sciences·C LarsonR B Weinberg
Apr 1, 1997·Digestive Diseases and Sciences·M A MohiuddinD O Castell
Jun 1, 1997·Digestive Diseases and Sciences·M J LevyJ E Ranney

❮ Previous
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Citations

Mar 12, 2003·Current Treatment Options in Gastroenterology·Mitchell J. Spirt
Jun 8, 2001·Clinical Therapeutics·A E ZimmermannD Levine
Apr 12, 2003·Surgical Oncology·Jade S HiramotoJeffrey A Norton
May 24, 2003·Best Practice & Research. Clinical Gastroenterology·Donald R Duerksen
Oct 3, 2007·Nature Clinical Practice. Gastroenterology & Hepatology·Frank H Klebl, Jürgen Schölmerich
Sep 1, 1999·Alimentary Pharmacology & Therapeutics·V K SharmaC W Howden
Jan 13, 2000·Alimentary Pharmacology & Therapeutics·W L TsaiG H Chen
May 15, 2002·Critical Care Medicine·David W Noble
Jan 12, 2001·Journal of Clinical Gastroenterology·J R Pisegna
Feb 13, 2002·Journal of Pediatric Gastroenterology and Nutrition·Stuart S KaufmanAlan N Langnas
Jul 20, 2002·The Journal of Trauma·Hakan GuvenKayhan Ozkan
Oct 16, 2004·Critical Care Medicine·Ryan J DaleyFrederick B Rogers
Jun 9, 2005·Critical Care Medicine·Jean-Louis Vincent
Feb 26, 2005·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Julie A HaizlipDonald D Vernon
Dec 6, 2008·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Jitladda DeerojanawongNuanchan Prapphal
Feb 8, 2005·Critical Care : the Official Journal of the Critical Care Forum·Stephen Brett
May 7, 2008·Drugs·Vandana BoparaiGeorge Triadafilopoulos
Jul 17, 2014·Critical Care : the Official Journal of the Critical Care Forum·Mark P PlummerAdam M Deane
Mar 25, 2004·Clinical Therapeutics·Mitchell J Spirt
May 25, 2005·Dimensions of Critical Care Nursing : DCCN·Amy B Ziegler
Sep 26, 2008·Critical Care Nursing Quarterly·Harpriya SinghSandeep Sekhon
Jul 26, 2014·Expert Review of Pharmacoeconomics & Outcomes Research·Jayashri SankaranarayananKeith M Olsen
Nov 2, 2005·Expert Opinion on Pharmacotherapy·Donald Castell
Nov 17, 2012·The Surgical Clinics of North America·Jennifer Roberts, John A Weigelt
Nov 26, 2009·Journal of Critical Care·Cristina B Terzi CoelhoNelson Adami Andreollo
May 19, 2009·Gastroenterology Clinics of North America·Tauseef Ali, Richard F Harty
Jul 15, 2015·Chinese Journal of Traumatology = Zhonghua Chuang Shang Za Zhi·Li-Hong CuiSan-Dong Gong
Dec 17, 2008·Alimentary Pharmacology & Therapeutics·K M Olsen, J W Devlin
Mar 19, 2013·Acta Anaesthesiologica Scandinavica·M KragM H Møller
Dec 13, 2012·Pharmacoepidemiology and Drug Safety·Hojjat SalmasianCarol Friedman
Jul 1, 1999·Clinics in Chest Medicine·A LioliosE Benjamin
Jul 15, 2005·Journal of Critical Care·Neil Stollman, David C Metz
May 11, 2005·Current Medical Research and Opinion·David C Metz
Nov 21, 2014·Wiener klinische Wochenschrift·Kurt LenzMartin Voglmayr
Oct 7, 2005·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Charles F Seifert, Barbara A Johnston
Nov 28, 2002·The Annals of Pharmacotherapy·Rose Jung, Robert MacLaren
Apr 7, 2005·The Annals of Pharmacotherapy·Christian J Coursol, Sabrina E Sanzari
Apr 10, 2002·Critical Care Nursing Clinics of North America·Jeanne Flannery, Denise A Tucker
May 1, 2009·Expert Review of Clinical Pharmacology·Alex Mejia, Walter K Kraft
May 14, 2008·Gastroenterology·Mitchell L Schubert, David A Peura

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