PMID: 7333701Dec 1, 1981Paper

A prospective study of plasma prolactin levels and subsequent risk of breast cancer

International Journal of Cancer. Journal International Du Cancer
H G KwaJ Cuzick

Abstract

Plasma prolactin was measured in 2,572 pre-menopausal, 628 menopausal, and 1,666 peri- and post-menopausal women who were apparently healthy. Breast cancer was subsequently diagnosed in 47 of these women at a median time of 5 years after blood collection (pre-cancer cases). Prolactin levels in pre-menopausal cases increased significantly with age whereas this was not found in matched controls. The perimenopausal cases were characterized by extreme variability in prolactin levels. In post-menopausal women who developed breast cancer, the prolactin levels were significantly elevated, being at or above the 70th percentile for the controls. In this group the results are consistent with prolactin acting as a late-stage tumour promoter.

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Citations

Apr 1, 1986·European Journal of Cancer & Clinical Oncology·D Y WangR D Rubens
Dec 1, 1989·British Journal of Obstetrics and Gynaecology·H S CuckleD R Hughes
Oct 1, 1992·Mayo Clinic Proceedings·A J Martinez
Jun 29, 2012·Veterinary and Comparative Oncology·E MichelI M Reichler
Jun 1, 1988·European Journal of Cancer & Clinical Oncology·D Y WangH G Kwa
Dec 15, 1984·International Journal of Cancer. Journal International Du Cancer·J BurchellJ Taylor-Papadimitriou
Jan 15, 1987·International Journal of Cancer. Journal International Du Cancer·B G Ward, D J Cruickshank
Nov 15, 1986·International Journal of Cancer. Journal International Du Cancer·J W MooreR D Bulbrook
Sep 15, 1984·International Journal of Cancer. Journal International Du Cancer·W HoltkampD von Heyden
Dec 15, 1983·International Journal of Cancer. Journal International Du Cancer·J CuzickJ L Hayward
Jan 29, 1987·The New England Journal of Medicine·V C MuseyJ R Preedy
Mar 5, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ana B F Emiliano, Julie L Fudge
Aug 19, 2008·Journal of Psychopharmacology·Philip W HarveyChristopher J Springall
Jun 15, 1983·Cancer·M B Lipsett
Jun 1, 1984·Asia-Oceania Journal of Obstetrics and Gynaecology·R J Pepperell

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